ArticleNature communications2025
Large field-of-view volumetric deep brain imaging through gradient-index lenses.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Spiral scan and cylindrical deconvolution to maximize image volume and contrast of multiphoton GRIN microendoscopy.Biomedical optics express · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
The rapid advance of genetically encoded fluorescent functional indicators has transformed neuroscience research. Fluorescence-based optical neural recording offers excellent sensitivity and spatiotemporal resolutions. A major limitation of optical measurement is the superficial access depth due to the random light scattering in the mammalian brain. Currently, implanting miniature gradient-index (GRIN) lenses has become the preferred method for deep brain optical imaging. However, the image quality and throughput are majorly impacted by the severe optical aberration of GRIN lenses. In this work, we present an easy-to-adopt solution to overcome these challenges and improve the image quality, volume, and throughput. Specifically, we develop a correction objective lens that corrects the aberration of a GRIN lens to enable high-throughput volumetric functional imaging with a ~ 400% larger field-of-view (FOV). We demonstrate the capabilities of in vivo large-FOV 3D volumetric calcium imaging by recording over 1000 neurons in deep brain regions through a 0.5 mm diameter GRIN lens. The simplicity and robust performance of the method promise broad applications in neuroscience research.
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Registered trials
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