Hmox1 expression indicates distinct injury phenotypes of proximal tubule cells in sepsis-associated acute kidney injury.

Yifei He, Weiru Zhang, Zhilan Li, Chenxi Liu, Yi Peng

Abstract read

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Yifei HeDepartment of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Weiru ZhangDepartment of General Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Zhilan LiDepartment of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Chenxi LiuDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.

Yi PengDepartment of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China. amou11111@126.com.

Funding

Natural Science Foundation of Hunan province 2023JJ30973

6 · The paper itself

Abstract

Sepsis-associated acute kidney injury (SAKI) is the most common organ dysfunction in sepsis and a significant contributor to high mortality rates. Despite its clinical importance, the underlying pathogenesis of SAKI remains unclear, and effective therapies are currently lacking. This study aims to identify specific biomarkers for SAKI diagnosis by integrating bulk and single-cell RNA sequencing data from renal tissues in the SAKI model. We analyzed changes in mRNA/protein expression and cellular localization in kidney tissues affected by SAKI and confirmed that Hmox1 has potential as an indicator of proximal tubule (PT) injury in SAKI. Further validation across mouse models, and patient samples confirmed the role of Hmox1 in SAKI. Notably, we observed that Hmox1 high- and low-expressing PT cell subsets exhibit distinct phenotypes in SAKI. The Hmox1

Indexed as

Acute Kidney InjuryHeme Oxygenase-1Kidney Tubules, ProximalSepsisAnimalsBiomarkersDisease Models, AnimalHumansMacrophagesMaleMembrane ProteinsMiceMice, Inbred C57BLPhenotypeBiomarkersHeme Oxygenase-1HMOX1 protein, humanHmox1 protein, mouseMembrane ProteinsAcute kidney injuryBiomarkerHmox1Proximal tubuleSepsis

Identifiers

PMID41145479

DOI10.1038/s41598-025-05764-w

PMCPMC12559336

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.