Evidence map›Paper›PMID 41145478›Full record

ArticleNature communications2025

Dynamic radical recombination enabling stereodivergent construction of spirocycles with nonadjacent stereocenters.

Zheng Sun, Jichao Huang, Jiangtao Ren, Kaixin Zhao, Xixiang Chen, Jing Liang, Yifan Li, Fangzhi Peng, Yi Jin, Yingqing Ou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zheng Sun *Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Jichao Huang *College of Chemistry, Central China Normal University, Wuhan, China.ORCID http://orcid.org/0009-0008-0037-1932
Jiangtao Ren *Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Kaixin ZhaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Xixiang ChenShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, School of Integrative Medicine and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jing LiangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Yifan LiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Fangzhi PengKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Yi JinKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China. jinyi@ynu.edu.cn.ORCID http://orcid.org/0000-0003-0149-2150
Yingqing OuDepartment of Chemistry, National University of Singapore, Singapore, Singapore. yqou@nus.edu.sg.
Jianrong XuShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, School of Integrative Medicine and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. jianrong.xu@shutcm.edu.cn.
Zhihan ZhangCollege of Chemistry, Central China Normal University, Wuhan, China. zhihanzhang@ccnu.edu.cn.ORCID http://orcid.org/0000-0002-1758-3914
Zhihui ShaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China. zhihui_shao@hotmail.com.ORCID http://orcid.org/0000-0003-4531-3417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chiral spirocyclic scaffolds have garnered significant attention in drug discovery and chiral ligand development due to their rigid structures and potential bioactive properties, yet stereodivergent synthesis of such systems, particularly those bearing non-adjacent stereocenters, remains a formidable challenge. Herein, we report a dynamic radical recombination (DRR) strategy that enables cobalt-hydride-catalyzed ligand-controlled stereodivergent olefin hydroalkylation, delivering a series of spirocyclic compounds bearing 1,3-non-adjacent stereocenters with up to >99:1 er and >20:1 dr. Density functional theory (DFT) calculations reveal that different ligands induce distinct reaction mechanism, resulting in diastereoselectivity reversal through dynamic radical recombination pathway. Biological evaluations demonstrate that selected newly synthesized spirocyclic products markedly suppress lipopolysaccharide (LPS)-induced neuroinflammation in microglial cells, effectively reducing pro-inflammatory cytokine levels (TNF-α, IL-6, IL-1β) and restoring cells to pre-inflammatory states.

Indexed as

Anti-Inflammatory AgentsSpiro CompoundsAlkenesAnimalsCatalysisCell LineCobaltCytokinesLigandsLipopolysaccharidesMiceMicrogliaStereoisomerismAlkenesAnti-Inflammatory AgentsCobaltCytokinesLigandsLipopolysaccharidesSpiro Compounds

Identifiers

PMID41145478
PMCPMC12559201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.