Evidence map›Paper›PMID 41145461›Full record

ArticleRenal failure2025

Leukocyte telomere length mediates the association between SIRI and CKD: insights from NHANES 1999-2002.

Xiangyun Dang, Guiqing Xu, Huixian Li, Yiqun Hao, Xiaotian Zhang, Xiaoyong Yu, Zhenpeng Zhou, Xueying Liu, Wentao Zhang, Wanhong Lu and 1 more

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In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xiangyun DangDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Guiqing XuDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Huixian LiDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yiqun HaoDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaotian ZhangDepartment of Human Anatomy, Histology and Embryology, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Xiaoyong YuDepartment of Nephrology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, China.
Zhenpeng ZhouDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xueying LiuDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wentao ZhangXi'an Jiaotong University, Xi'an, China.
Wanhong LuDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Li JinDepartment of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is closely linked to systemic inflammation and accelerated cellular aging. However, the role of the systemic inflammation response index (SIRI) and leukocyte telomere length (LTL), a biomarker of cellular aging, in the development and progression of CKD remain incompletely elucidated.

methodsWe analyzed cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) (1999-2002), which included 3805 individuals. Participants were divided into subgroups: (1) CKD versus non-CKD and (2) SIRI quartiles (Q1-Q4). SIRI was calculated as (monocytes × neutrophils)/lymphocytes. CKD was defined by urinary albumin to creatinine ratio (UACR) ≥30 mg/g or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m

resultsParticipants with CKD exhibited significantly higher SIRI values (

conclusionSystemic inflammation, as quantified by the SIRI, has a significant impact on CKD risk through its contribution to LTL attrition. This process highlights the complex interplay between systemic inflammation and biological aging in the pathophysiology of CKD.

Indexed as

InflammationLeukocytesRenal Insufficiency, ChronicTelomereAdultAgedBiomarkersCellular SenescenceCross-Sectional StudiesDisease ProgressionFemaleGlomerular Filtration RateHumansMaleMiddle AgedNutrition SurveysBiomarkerschronic kidney diseaseNHANESSystemic inflammation response indextelomere length

Identifiers

PMID41145461
PMCPMC12570250

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