Evidence map›Paper›PMID 41145440›Full record

ArticleCell death & disease2025

YTHDC2 suppresses bladder cancer by inhibiting SOX2-mediated tumor plasticity.

Yi Cai, Cong Zhu, Ming-Hui Shi, Jin-Hui Zhang, Shu-Yan Liu, Jin-Long Cui, Meng-Meng Guo, Dao-Jing Ming, Xian-Tao Zeng, Shuai Yuan and 1 more

Abstract read
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The mCells · 2026
    Review
  2. Review
  3. The relevance of mJournal of cancer research and clinical oncology · 2026
    Review
  4. The Journal of international medical research · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yi Cai *Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Cong Zhu *Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Ming-Hui Shi *Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jin-Hui ZhangLaboratory of Molecular and Cellular Biology, Institute of Metabolism and Health, School of Basic Medical Sciences, Department of General Surgery of Huaihe Hospital, Henan University, Kaifeng, Henan, China.
Shu-Yan LiuCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jin-Long CuiCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Meng-Meng GuoDepartment of Urology, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Dao-Jing MingCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xian-Tao ZengCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. zengxiantao1128@whu.edu.cn.ORCID http://orcid.org/0000-0003-1262-725X
Shuai YuanCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. yuanshuai021@whu.edu.cn.ORCID http://orcid.org/0000-0002-8503-612X
Hong WengCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. wenghong@whu.edu.cn.ORCID http://orcid.org/0000-0001-7795-5671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pluripotent cancer stem cells play a pivotal role in inducing phenotypic plasticity across various cancer types, including bladder cancer. This plasticity, crucial for cancer progression, is largely regulated by epigenetic modifications including N6-methyladenosine (m

Indexed as

Cell PlasticityNerve Tissue ProteinsRNA-Binding ProteinsSOXB1 Transcription FactorsUrinary Bladder NeoplasmsAdenosineAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMiceNeoplastic Stem CellsRNA HelicasesAdenosineNerve Tissue ProteinsN-methyladenosineRNA-Binding ProteinsRNA HelicasesSOX2 protein, humanSOXB1 Transcription FactorsYTHDC2 protein, human

Identifiers

PMID41145440
PMCPMC12559364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.