Evidence map›Paper›PMID 41145419›Full record

ArticleNature communications2025

Tissue localization of natural killer cells dictates surveillance of lung metastasis.

Marijne Vermeer, Colin Sparano, Nicolò Coianiz, Maud Mayoux, Gioana Litscher, André Fonseca, Stanislav Dergun, Caroline Mussak, Lukas Rindlisbacher, Philipp Häne and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Reinvigorating COTL1Nature cell biology · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marijne VermeerInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5869-0532
Colin SparanoInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Nicolò CoianizInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-4357-0359
Maud MayouxInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-3700-3120
Gioana LitscherInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
André FonsecaInflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Stanislav DergunInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0000-7201-9032
Caroline MussakInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Lukas RindlisbacherInflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Philipp HäneInflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0007-5197-3338
Laura DucimetièreInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Tobias WertheimerDepartment of Internal Medicine I (Hematology, Oncology and Stem Cell Transplantation), University Medical Center Freiburg, Freiburg im Breisgau, Germany.
Burkhard BecherInflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1541-7867
Lothar C DieterichEuropean Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0001-7908-5710
Sònia TuguesInnate Lymphoid Cells and Cancer, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. tugues@immunology.uzh.ch.ORCID http://orcid.org/0000-0003-1206-3386

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lung is a common metastatic site for various cancer types. Successful immune surveillance of lung metastasis depends on Natural Killer (NK) cells, but the underlying mechanisms are elusive. Here, we show that the pulmonary vasculature recruits and maintains highly cytotoxic, differentiated CD11b

Indexed as

Immunologic SurveillanceKiller Cells, NaturalLung NeoplasmsAnimalsCD11b AntigenCell DifferentiationCell Line, TumorCell MovementFemaleHumansLungMiceMice, Inbred C57BLTransforming Growth Factor betaTumor Necrosis Factor Receptor Superfamily, Member 7CD11b AntigenTransforming Growth Factor betaTumor Necrosis Factor Receptor Superfamily, Member 7

Identifiers

PMID41145419
PMCPMC12559431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.