Evidence map›Paper›PMID 41145411›Full record

ArticleNature communications2025

CRL4

Anoop Kumar Yadav, Alikhan Abdirov, Katarina Ondruskova, Simran Negi, Kristina Jamrichova, Karolina Kolarova, Nikol Dibus, Jana Krejci, Hana Polasek-Sedlackova, Lukas Cermak

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Ubiquitination-Driven Reprogramming of Proteostasis in Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anoop Kumar Yadav *Institute of Biophysics, Czech Academy of Sciences, Brno, Czechia.ORCID http://orcid.org/0000-0001-6186-4599
Alikhan Abdirov *Laboratory of Cancer Biology, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czechia.
Katarina OndruskovaLaboratory of Cancer Biology, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czechia.
Simran NegiInstitute of Biophysics, Czech Academy of Sciences, Brno, Czechia.ORCID http://orcid.org/0009-0006-5573-3449
Kristina JamrichovaLaboratory of Cancer Biology, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czechia.
Karolina KolarovaLaboratory of Cancer Biology, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czechia.
Nikol DibusLaboratory of Cancer Biology, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czechia.ORCID http://orcid.org/0000-0003-2743-352X
Jana KrejciInstitute of Biophysics, Czech Academy of Sciences, Brno, Czechia.ORCID http://orcid.org/0000-0001-5204-0723
Hana Polasek-SedlackovaInstitute of Biophysics, Czech Academy of Sciences, Brno, Czechia. polasek-sedlackova@ibp.cz.ORCID http://orcid.org/0000-0001-8234-6176
Lukas CermakLaboratory of Cancer Biology, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czechia. lukas.cermak@img.cas.cz.ORCID http://orcid.org/0000-0002-8777-3692

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101090292European Molecular Biology Organization (EMBO) IG-5689-2024Grantová Agentura České Republiky (Grant Agency of the Czech Republic) 22-20303MGrantová Agentura České Republiky (Grant Agency of the Czech Republic) 25-18085S
6 · The paper itself

Abstract

The minichromosome maintenance (MCM2-7) protein complexes are central drivers of genome duplication. Distinct protein pools, parental and nascent MCMs, and their precise equilibrium are essential to sustain error-free DNA replication. However, the mechanism responsible for generating these pools and maintaining their equilibrium remains largely unexplored. Here, we identified CRL4

Indexed as

Cell Cycle ProteinsDNA ReplicationMinichromosome Maintenance ProteinsAdaptor Proteins, Signal TransducingCell NucleusChromatinGenomic InstabilityHeLa CellsHumansMinichromosome Maintenance Complex Component 2Minichromosome Maintenance Complex Component 3Minichromosome Maintenance Complex Component 7Nuclear ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsChromatinMCM2 protein, humanMCMBP protein, humanMinichromosome Maintenance Complex Component 2Minichromosome Maintenance Complex Component 3Minichromosome Maintenance Complex Component 7Minichromosome Maintenance ProteinsNuclear Proteins

Identifiers

PMID41145411
PMCPMC12559739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.