ArticleJournal of diabetes investigation2026
Effect of remnant cholesterol on the onset of diabetes mellitus.
Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- A Narrative Review of Remnant Cholesterol as an Independent Atherogenic Lipoprotein in Type 2 Diabetes: Pathophysiology and Clinical Implications.Therapeutics and clinical risk management · 2026Review
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHigher levels of remnant cholesterol (Rem-C) are associated with diabetic conditions, serving as a treatment target and surrogate marker for identifying high-risk groups for diabetes mellitus (DM) onset. However, the effect of Rem-C on DM onset based on sex and age remains unclear. We aimed to examine the association between Rem-C levels and DM onset, stratified by sex and age.
methodsIn this health checkup-based retrospective cohort study, we analyzed data from 13,952 participants who underwent medical checkups two or more times at the Ehime General Health Care Association between April 2003 and March 2021, a non-hospital facility where health care services are provided to company employees and local residents. The mean follow-up period was 4.66 years. Cox proportional hazard models were used to assess the association between Rem-C and DM onset.
resultsIn the multivariate analysis, higher Rem-C levels were associated with DM onset in individuals aged <50 years (men: adjusted hazard ratio [aHR] = 1.81, 95% CI: 1.46-2.20; women: aHR = 2.13, 95% CI: 1.18-3.37). However, this association was not observed in those aged ≥50 years. Triglycerides (TG) were also significantly associated with DM onset in younger adults, with slightly higher predictive ability (AUC) than Rem-C, particularly among younger women. Sensitivity analyses using continuous age as a variable showed similar trends.
conclusionsRem-C and TG may be useful predictors of DM onset in younger adults, with TG showing slightly better performance. Age-specific strategies may improve early DM prevention.
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