SynthesisYonsei medical journal2025
Adherence to Animal Research: Reporting of In Vivo Experiments Guidelines in Stem Cell Studies in Animal Models of Parkinson's Disease: A Systematic Review.
Synthesis in Yonsei medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeThe Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were published in 2010 and revised in 2020 to improve the reporting of preclinical animal studies. The present study evaluated the reporting of animal stem cell research related to Parkinson's disease (PD). MATERIALS AND
methodsArticles on this topic published up to October 18, 2024, were systematically searched in relevant databases. For each individual study, we analyzed the proportion of subsets that were reported, partially reported, or unreported for each of the 38 ARRIVE 2.0 items. We compared reporting before and after the publication of the ARRIVE guidelines, and analyzed compliance score changes over time and by country.
resultsWe analyzed 90 animal studies related to PD. None of the studies reported sample size calculations, adverse event reporting, or humane endpoints. Additionally, only about 20% or less of the studies reported on strategies to minimize potential confounders, inclusion or exclusion of animal conditions, limitations, allocation methods, and pre-protocol enrollment. We observed no substantial improvement in adherence after publication of the guidelines or over time.
conclusionThe reporting of key design principles in animal stem cell research related to PD was insufficient both before and after the introduction of the ARRIVE guidelines in 2010. Both researchers and journal editors should pay more attention to the accurate, comprehensive reporting of animal studies.
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Registered trials
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