Evidence map›Paper›PMID 41145211›Full record

ArticleLife science alliance2026

Loss of

Fangkun Luan, Yunqiao Li, Jia Ning, Jenny Tuyet Tran, Tanya R Blane, Raag Bhargava, Zhe Huang, Changchun Xiao, David Nemazee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fangkun LuanThe School of Medicine, Nankai University, Tianjin, China.
Yunqiao LiDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-9937-1634
Jia NingMolecular and Cell Biology Laboratory, The Salk Institute, La Jolla, CA, USA.
Jenny Tuyet TranDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Tanya R BlaneDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Raag BhargavaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Zhe HuangDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Changchun XiaoDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
David NemazeeDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA nemazee@scripps.edu yunli@scripps.edu cxiao@scripps.edu.ORCID 0000-0002-4769-6311

Funding

Functional Analysis of MicroRNAs and Target Genes in Immune ToleranceR01AI137252 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 2019 to 2024
$2.9M
NIAID NIH HHS R01 AI137252
6 · The paper itself

Abstract

T cells are one of the most powerful weapons to fight cancer; however, T-cell exhaustion and dysfunction restrict their long-lasting function in antitumor immunity. B-cell lymphoma 6 (BCL6) has many functions in CD8 T cells; however, it is unclear how it regulates the effector function and exhaustion of CD8 cells. Overall, a low level of BCL6 mRNA in human cancer samples is associated with better outcomes, but high expression of BCL6 is specifically observed in cytotoxic CD8 T cells. We found that BCL6 deficiency in activated CD8 T cells enhanced tumor repression in multiple mouse models. More IL-2-expressing CD8 T cells and reduced proportions of exhausted or dysfunctional CD8 T cells were detected within tumors when

Indexed as

CD8-Positive T-LymphocytesGlycolysisNeoplasmsProto-Oncogene Proteins c-bcl-6AnimalsCell Line, TumorHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutBCL6 protein, humanBcl6 protein, mouseProto-Oncogene Proteins c-bcl-6

Identifiers

PMID41145211
PMCPMC12559151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.