Evidence map›Paper›PMID 41144946›Full record

ArticlePhysiological reports2025

Impact of respiratory muscle training on exercise tolerance in hypobaric hypoxia: A pilot study in adult males.

Scott K Ferguson, Michael Miller, Luke Yeager, Annie Wislowski, Andrew Subudhi, Robert C Roach

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Scott K FergusonIntegrative Aerospace and Exercise Physiology Laboratory (IAEP), Department of Human Factors, College of Arts and Sciences, Embry-Riddle Aeronautical University, Daytona Beach, Florida, USA.ORCID 0000-0002-4446-6131
Michael MillerAltitude Research Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.
Luke YeagerAltitude Research Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.
Annie WislowskiAltitude Research Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.
Andrew SubudhiAltitude Research Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.
Robert C RoachAltitude Research Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, Colorado, USA.

Funding

HHS | National Institutes of Health (NIH) 2L30HL134123-03US Special Operations Command
6 · The paper itself

Abstract

Hypoxia and certain chronic diseases can increase the work of breathing, potentially impacting the muscle hyperemic response during exercise and overall exercise performance. Respiratory muscle training (RMT) has been observed to decrease perceived effort under hypoxic conditions; however, it remains unclear if RMT affects exercise performance in acute hypoxia. We investigated whether 4 weeks of RMT could enhance submaximal and maximal exercise performance in hypoxia (barometric pressure = 425 mmHg, ~4876 m). Seven adult males underwent a 250 kJ submaximal (target RPE 15-17) cycling trial in hypoxia, followed by an incremental test to maximal exertion. After 4 weeks of RMT under normoxic conditions, these tests were repeated in hypoxia. After RMT, RPE showed no significant difference during the submaximal test (Pre-RMT: 16 ± 0.45, Post-RMT: 16 ± 0.45, p > 0.05) despite an increase in HR (Pre-RMT:154 ± 16, Post-RMT: 161 ± 12, p < 0.05). There were no significant differences in submaximal exercise performance. However, RMT did raise maximal oxygen uptake (V̇O

Indexed as

Breathing ExercisesExercise ToleranceHypoxiaRespiratory MusclesAdultHumansMaleOxygen ConsumptionPilot ProjectsYoung Adultexercise performanceexercise tolerancehypobaric hypoxiasimulated altitudeV̇O2max

Identifiers

PMID41144946
PMCPMC12558598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.