ArticleActa paediatrica (Oslo, Norway : 1992)2026
The Effect of Conjugated Bilirubin on the Measurement of Unbound Bilirubin.
Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Determinants of unbound bilirubin and clinical utility of the total bilirubin/albumin ratio in neonates.Pediatric research · 2026Article
- A LASSO-based nomogram for predicting acute bilirubin encephalopathy in newborns with severe hyperbilirubinemia.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
aimUnbound bilirubin (Bf) is a stronger predictor of neurotoxicity in newborns than that of total serum bilirubin (TSB). Standard Bf assays rely on peroxidase methods (e.g., Arrows analyser), whereas UBCheck employs a near-infrared fluorescence sensor. Because conjugated bilirubin (CBR) levels are often elevated in infants, they may alter Bf measurement accuracy, particularly with peroxidase-based methods. This study compared CBR effects on Bf measurement results from the UBCheck and Arrows assays and evaluated whether they reflected albumin displacement, assay interference, or both.
methodsBilirubin-albumin complexes were spiked with CBR (0.1-5 mg/dL). Bf was measured with both assays using a three-stage paired-sample protocol to assess displacement and interference.
resultsAt CBR ≤ 0.2 mg/dL, both assays yielded comparable Bf values. At 0.5-3 mg/dL, Arrows showed 12%-120% Bf increases, while UBCheck remained stable. At 4 mg/dL, UBCheck rose 20%, and Arrows increased by 220%. High CBR acted as both interferent and displacer.
conclusionsIn the presence of neonatal CBR concentrations, UBCheck provides reliable Bf measurements, whereas Arrows substantially overestimates Bf, limiting its clinical utility.
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