Evidence map›Paper›PMID 41144781›Full record

ArticleJournal of applied clinical medical physics2025

Using large language models to automate summarization of CT simulation orders in radiation oncology.

Meiyun Cao, Shaw Hu, Jason Sharp, Edward Lee Clouser, Jason M Holmes, Linda L Lam, Xiaoning Ding, Diego Santos Toesca, Brianne C Raulston, Wendy S Lindholm and 4 more

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meiyun CaoDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Shaw HuCorcoran College of Arts and Sciences, George Washington University-Washington DC, Washington DC, USA.
Jason SharpDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Edward Lee ClouserDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.ORCID https://orcid.org/0009-0009-5900-9433
Jason M HolmesDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Linda L LamDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Xiaoning DingDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Diego Santos ToescaDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Brianne C RaulstonDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Wendy S LindholmDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Samir H PatelDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Sujay A VoraDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Peilong WangDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0002-6730-1524
Wei LiuDepartment of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0003-0935-3999

Funding

Dose Linear Energy Transfer Volume Histogram and Dosimetric Seed Spot Analysis in Spot Scanning Proton TherapyR01CA280134 · NCI · MAYO CLINIC ARIZONA · PI Wei Liu · 2024 to 2026
$1.7M
Eric & Wendy Schmidt Fund for AI Research & InnovationFred C. and Katherine B. Anderson FoundationKemper Marley FoundationNCI NIH HHS R01 CA280134NCI NIH HHS R01CA280134
6 · The paper itself

Abstract

backgroundIn the current clinical workflow of radiation oncology, therapists manually summarize the physician-issued Computed Tomography (CT) simulation orders to prepare patients' CT simulations. This process increases the workload, introduces variability in documentation quality, and is prone to human errors. PURPOSE: This study aims to address these challenges using a large language model (LLM) to automate the generation of summaries from the CT simulation orders and evaluate its performance.

methodsA total of 607 CT simulation orders were collected from the Aria database at our institution. A locally hosted LLaMa 3.1 405B model, accessed via the Application Programming Interface (API) service, was used to extract keywords from the CT simulation orders and generate summaries. The downloaded CT simulation orders were categorized into seven groups based on treatment modalities and disease sites. For each group, a customized instruction prompt was developed collaboratively with therapists to guide the LLaMa 3.1 405B model in generating summaries. The ground truth for the corresponding summaries was manually derived by carefully reviewing each CT simulation order and subsequently verified by therapists. The accuracy of the LLM-generated summaries was evaluated by therapists using the ground truth.

resultsOver 98% of the LLM-generated summaries aligned with the ground truth in terms of accuracy. Our evaluations showed an improved consistency in format and enhanced readability from the LLM-generated summaries compared to the corresponding therapist-generated summaries. This automated approach demonstrated consistent performance across all groups, regardless of treatment modality or disease site.

conclusionsThis study demonstrated the high precision and consistency of the LLaMa 3.1 405B model in extracting keywords and summarizing CT simulation orders, suggesting that LLMs have great potential to assist in this task, reduce the workload of CT simulation therapists and improve radiation oncology workflow efficiency.

Indexed as

NeoplasmsProgramming LanguagesRadiation OncologyRadiotherapy Planning, Computer-AssistedTomography, X-Ray ComputedComputer SimulationHumansLarge Language ModelsWorkflowatomizationCT simulation orderlarge language modelradiation oncologysummary

Identifiers

PMID41144781
PMCPMC12558592

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.