Evidence map›Paper›PMID 41144769›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment.

Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Nanozyme-based therapeutic strategies for traumatic brain injury.International journal of pharmaceutics: X · 2026
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  18. Emerging Nanozyme Strategies for Precision Breast Cancer Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jian ZangThe first Hospital of China Medical University, Liaoning, 110001, China.
Zhaozhou RenShengjing Hospital of China Medical University, Liaoning, 110004, China.
Haibo WangThe first Hospital of China Medical University, Liaoning, 110001, China.
Xing YangThe first Hospital of China Medical University, Liaoning, 110001, China.
Yang SongShengjing Hospital of China Medical University, Liaoning, 110004, China.
Jun LiaoInstitute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.ORCID https://orcid.org/0000-0002-3180-2685
Xiaoying LiThe first Hospital of China Medical University, Liaoning, 110001, China.

Funding

China Medical University CMU-2504National Natural Science Foundation of China 82203162
6 · The paper itself

Abstract

Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates. While traditional treatment strategies such as surgery, radiation therapy, chemotherapy and targeted therapy have made significant progress, limitations such as tumor heterogeneity, drug resistance, distant metastasis, and systemic side effects remain urgent issues to address. Nanozymes, a new type of nanomaterial with natural enzyme activity, have provided revolutionary opportunities for the precise treatment of breast cancer. This article aims to comprehensively review the progress of nanozyme applications in breast cancer treatment, focusing on how they can improve immunotherapy by regulating the tumor microenvironment and enhancing the immune response, optimize chemotherapy by improving drug delivery efficiency and overcoming drug resistance, and develop photothermal/photodynamic combination therapy to enhance therapeutic efficacy. In addition, this paper will also analyze in depth the key challenges faced by nanozymes in the clinical translation of breast cancer, such as biocompatibility, targeting efficiency, controllability, and large-scale production, and look forward to its broad prospects as a new treatment method combined with existing strategies, with the hope of providing new ideas for the precise, efficient, and low-toxicity treatment of breast cancer in the future.

Indexed as

Breast NeoplasmsNanostructuresPrecision MedicineAnimalsDrug Delivery SystemsFemaleHumansImmunotherapyPhotochemotherapyTumor Microenvironmentbreast cancerclinical translationnanomedicinenanozymetumor microenvironment

Identifiers

PMID41144769
PMCPMC12697830

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.