Evidence map›Paper›PMID 41144739›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

T1WI-SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease.

Minghua Li, Aijun Shen, Xiaolong Gao, Chao Lin, Zongliang Huang, Qi Lv, Junjun Tang, Xiaolong Ma, Jiong Ni, Ju Tian and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Minghua LiDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Aijun ShenDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Xiaolong GaoDepartment of Radiology, Luodian Hospital, Shanghai University, Shanghai, 201908, P. R. China.
Chao LinDepartment of Periodontology, School and Hospital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, 200072, P. R China.
Zongliang HuangDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Qi LvDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Junjun TangDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Xiaolong MaDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Jiong NiDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Ju TianDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Jiaqi WuDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Xiaowen XuDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Wei WangDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.
Peijun WangDepartment of Medical Imaging, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, P. R. China.ORCID https://orcid.org/0000-0001-9128-6013

Funding

Clinical Research Plan of SHDC SHDC2020CR1038BNational Key R&D Program of China 2022YFC2009900National Key R&D Program of China 2022YFC2009904National Natural Science Foundation of China 81830059National Natural Science Foundation of China 82102023National Natural Science Foundation of China 82227807Research Project of Shanghai Municipal Health Commission 20224Y0340Research Project of Shanghai Municipal Health Commission 2022JC017
6 · The paper itself

Abstract

Beta-site APP-cleaving enzyme 1 (BACE1), a critical rate-limiting enzyme that synthesizes β-amyloid peptide (Aβ), is an important marker of early pathological changes in Alzheimer's disease (AD). Early small plaques cannot be accurately detected using traditional Magnetic resonance imaging (MRI) probes. Therefore, magnetic resonance tuning (MRET) and susceptibility weighted imaging (SWI)-based smart responsive MR nanoprobes are designed to achieve the sensitive detection of BACE1 and Aβ plaques. This probe is modified with a blood-brain barrier-penetrating targeting peptide that enables its reach to the AD microenvironment. The enhancement of T1WI signals owing to the MRET effect caused by the separation of probes in response to BACE1 is used to reflect real-time BACE1 changes. When Aβ plaques are present, the remaining probes that bound around Aβ plaques underwent in situ thiol cross-linking under the action of peroxynitrite (ONOO

Indexed as

Alzheimer DiseaseMagnetic Resonance ImagingAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesEarly DiagnosisHumansMicePlaque, AmyloidAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAspartic Acid Endopeptidasesalzheimer's diseasemagnetic resonance imagingmagnetic resonance tuningsusceptibility weighted imaging

Identifiers

PMID41144739
PMCPMC12767124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.