Evidence map›Paper›PMID 41144720›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2026

Efficacy of functional alignment in total knee arthroplasty in restoring in vivo cruciate ligament forces and knee kinematics compared with mechanical alignment.

Kenichi Kono, Hiroshi Inui, Tomofumi Kage, Takaharu Yamazaki, Shuji Taketomi, Darryl D'Lima, Tetsuya Tomita, Sakae Tanaka

Abstract readComparative Study
In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kenichi KonoDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8033-2037
Hiroshi InuiDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Tomofumi KageDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Takaharu YamazakiDepartment of Informatics, Faculty of Informatics, Shonan Institute of Technology, Kanagawa, Japan.
Shuji TaketomiDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Darryl D'LimaDepartment of Molecular Medicine Arthritis Research, The Scripps Research Institute, San Diego, California, USA.
Tetsuya TomitaDepartment of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan.
Sakae TanakaDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

Japanese Orthopaedic Society of Knee Arthroscopy and Sports Medicine FoundationJapanese Society for Replacement Arthroplasty Foundation 2023-RP02
6 · The paper itself

Abstract

purposeThe impact of coronal alignment on cruciate ligament forces in bicruciate-retaining total knee arthroplasty (TKA) remains unclear. We aimed to clarify in vivo cruciate ligament forces and knee kinematics among mechanically aligned (MA) and functionally aligned (FA) TKAs and normal knees.

methodsNormal, MA TKA and FA TKA knees were assessed during squatting using fluoroscopy. Tibiofemoral kinematics was measured using a two-dimensional/three-dimensional registration technique, including axial rotation, varus-valgus angle, and anteroposterior translation (APT) of the surgical epicondylar axis (SEA) and low contact points (LCPs). Ligament tensions during knee flexion were analysed in the anteromedial anterior cruciate ligament (aACL) and posterolateral anterior cruciate ligament (pACL) and anterolateral posterior cruciate ligament (aPCL) and posteromedial posterior cruciate ligament (pPCL).

resultsBoth MA and FA TKA knees exhibited greater external femoral rotation and less varus alignment. Medially, MA TKA knees were positioned more anteriorly at 0° flexion. Laterally, both TKA knees were positioned more posteriorly up to 10° flexion. Medially, MA TKA knees were positioned more anteriorly at 0° flexion. Laterally, both TKA knees were positioned more posteriorly up to 10° flexion. In lateral LCPs, both TKA knees were more anteriorly positioned. aACL and pACL tensions decreased with flexion, with no significant differences between TKA and normal knees, whereas aPCL and pPCL tensions increased with flexion. Beyond 80° flexion, MA TKA knees exhibited greater aPCL tension. Beyond 90° flexion, pPCL tension was higher in MA TKA knees.

conclusionsPCL tension was notably higher in MA TKA knees. However, FA TKA and MA TKA demonstrated comparable kinematics and changes in ACL force. Although FA TKA more closely restored the physiological balance of the cruciate ligaments, the overall effect appeared to be limited. LEVEL OF EVIDENCE: Level II.

Indexed as

Anterior Cruciate LigamentArthroplasty, Replacement, KneeKnee JointPosterior Cruciate LigamentAgedBiomechanical PhenomenaFemaleFluoroscopyHumansMaleMiddle AgedRange of Motion, ArticularTibiofemoral Jointcruciate ligament forcefunctional alignmenthigh‐flexion activitiesnormal kneetotal knee arthroplasty

Identifiers

PMID41144720
PMCPMC13327445

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.