Evidence map›Paper›PMID 41144701›Full record

ArticleVirulence2025

The GCN-2/eIF-2α/ATF-4 signaling pathway is involved in

Shawndra Wibisono, Phillip Wibisono, Yiyong Liu, Jingru Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shawndra WibisonoDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Phillip WibisonoDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Yiyong LiuDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Jingru SunDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.ORCID 0000-0003-1901-5600

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Neuronal and molecular mechanisms underlying neural regulation of innate immunityR35GM124678 · NIGMS · WASHINGTON STATE UNIVERSITY · PI Jingru Sun · 2017 to 2026
$4.5M
Molecular and neuronal mechanisms responsible for limiting stress responsesR35GM158259 · NIGMS · WASHINGTON STATE UNIVERSITY · PI Yiyong Liu · 2025 to 2026
$765k
NIGMS NIH HHS R35 GM124678NIGMS NIH HHS R35 GM158259NIH HHS P40 OD010440
6 · The paper itself

Abstract

In response to external or endogenous stress, eukaryotic cells can activate a common adaptive pathway called the integrated stress response (ISR). The ISR reduces global protein translation but upregulates the expression of stress response proteins to either restore cellular homeostasis or, in case of severe or prolonged stress, promote cell death. The bZIP transcription factor ATF4 plays a deciding role in cellular fate upon ISR activation, but the precise mechanisms underlying such decision-making remain unclear. Although bacterial infection has previously been observed to induce the ISR, the effects of this pathway on bacterial pathogenesis and host defense are not well understood. The functions of ATF4 in this process remain even more elusive. Using the

Indexed as

Activating Transcription Factor 4Caenorhabditis elegansCaenorhabditis elegans ProteinsEukaryotic Initiation Factor-2Salmonella entericaSignal TransductionAnimalsHost-Pathogen InteractionsRibosomal ProteinsStress, PhysiologicalActivating Transcription Factor 4Caenorhabditis elegans ProteinsEukaryotic Initiation Factor-2Ribosomal ProteinsATF-4C. elegansGCN-2/eIF-2α/ATF-4 signaling pathwayHost-pathogen interactionshost response to infectionintegrated stress responseribosomal proteinsSalmonella entericastress resistancestress response

Identifiers

PMID41144701
PMCPMC12574563

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.