ArticlePLoS pathogens2025
Structures of vesicular stomatitis virus glycoprotein G alone and bound to a neutralizing antibody.
Article in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Applying Raman Spectroscopy for Real-Time Monitoring of Ultra- and Diafiltration Steps in Viral Vector Purification.Pharmaceutics · 2026Article
- Review
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Authors and funding
10 authors.
Funding
Abstract
VSV G mediates viral entry via endocytosis. In the endosome, G undergoes a pH-dependent conformational change from pre- to post-fusion state, catalyzing membrane fusion. No complete structure of G has been reported so far. We present cryo-EM structures of G, isolated from virions using detergent, alone and in complex with the broadly neutralizing antibody 8G5F1 that binds all G conformations. The post-fusion structure reveals a novel rearrangement of the C-terminal part of the G ectodomain, showing that it undergoes a conformational rearrangement and stabilizes the post-fusion trimer by nesting into a groove between adjacent fusion domains. Structures of G-Fab complex show that the epitope belongs to a conserved antigenic site, explaining the broad neutralization capacity of the antibody. This work provides insights into the molecular basis of VSV G mediated fusion and antibody recognition, with potential implications for vaccine development, oncolytic virotherapy.
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Registered trials
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