Trial reportPloS one2025
Antibody response to tetanus, diphtheria, poliomyelitis, hepatitis B, and H. influenzae b vaccines in allogeneic hematopoietic stem cell transplant adult recipients: A multicenter trial.
Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03402776 (Impact of a Fourth Hexavalent Vaccine Dose During Primary Vaccination After Haematopoietic Stem Cell Transplantation), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of a Fourth Hexavalent Vaccine Dose During Primary Vaccination After Haematopoietic Stem Cell Transplantation
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNational and international guidelines recommend vaccinating hematopoietic stem cell transplant (HSCT) recipients, although relatively few studies have evaluated immunogenicity in adults. We therefore aimed to assess the immune response in adult allogeneic HSCT recipients vaccinated against tetanus, diphtheria, poliomyelitis, hepatitis B, and H. influenzae b.
methodWe conducted a multicenter prospective study. HSCT recipients were included at least 6 months post-transplantation (maximum: 24 months) if blood CD19 + lymphocytes were ≥0.1 G/L and plasma immunoglobulin ≥ 4g/L, and if no immunosuppressive therapy was applied. They received the hexavalent pediatric combination vaccine for tetanus, diphtheria, poliomyelitis, hepatitis B, and H. influenzae b (and pertussis) at months 0, 1, 2, and 12 (in addition to other recommended vaccines). Plasma antibodies against the five valences were quantified at inclusion and 1 month after the third and fourth doses.
resultsWe included 104 HSCT recipients (median age: 58 years [IQR:48-64]). Study vaccination was initiated a median of 11 months [IQR:9-14] after transplantation. Median [IQR] values for CD19 and plasma gammaglobulin at inclusion were 0.3 [0.2-0.6] G/L and 7.9 [6.4-11.1] g/L, respectively. Seroprotection after three doses and after the M12 booster was achieved for 97.2% and 97.5% of participants for tetanus, 100% and 97.5% for diphtheria, 96.6% and 92.7% for poliomyelitis, 78.3% and 84.1% for hepatitis B, and 94.6% and 95.0% for H. influenzae b. Adverse effects were benign.
conclusionVaccination against these five infections initiated during the first year post-allograft is immunogenic and should be performed in every recipient not undergoing immunosuppressive therapy.
trial registrationClinicalTrials.gov NCT03402776.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.