ArticlePloS one2025
Effects and mechanisms of engineered exosomes pretreated with Scutellaria baicalensis Georgi on osteoporosis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Stem Cell-Derived Extracellular Vesicles for the Treatment of Osteoporosis: A Systematic Review of Preclinical Evidence.Biomedicines · 2026Review
- Apple-Derived Vesicles Orchestrate Bone Regeneration:International journal of molecular sciences · 2026Article
- A Biocompatible Microdroplet Platform Incorporating MSC-Derived Exosomes for Bone Regeneration and Osteoporosis Treatment.International journal of nanomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis (OP) is a common systemic bone disease characterized by reduced bone mineral density and the degeneration of the microstructure of bone tissue. Current therapeutic strategies for OP confront limitations including suboptimal efficacy and substantial adverse effects. This study investigates the therapeutic potential of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) preconditioned with Scutellaria baicalensis Georgi (SBG) for osteoporosis management. Our findings demonstrate that SBG modulates the composition of BMSC-derived exosomes to potentiate osteogenesis. Furthermore, exosomes isolated from SBG-pretreated BMSCs (designated S-EXOs@BMSC) enhance osteogenic differentiation in MC3T3-E1 pre-osteoblasts, a process mediated by upregulating Semaphorin 3A (Sema3A). The efficacy of S-EXOs@BMSC in promoting bone regeneration was corroborated in a murine model of osteoporosis induced by ovariectomy (OVX). These results improve our understanding of how traditional Chinese medicine contributes to OP treatment and emphasize the potential of exosomes from BMSCs grown in SBG conditions as a novel therapeutic strategy for OP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.