Evidence map›Paper›PMID 41144174›Full record

ArticleThe international journal of cardiovascular imaging2025

Simultaneous measurement of coronary sinus flow and myocardial flow reserve using hybrid

Ayano Ikeda, Kenji Fukushima, Masataka Katahira, Naoyuki Ukon, Ryo Yamakuni, Joh Akama, Takeshi Shimizu, Takatoyo Kiko, Shiro Ishii, Masayoshi Oikawa and 2 more

Abstract readComparative Study
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In one paragraph

Article in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Quantitative imaging in medicine and surgery · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ayano IkedaDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Kenji FukushimaDepartment of Radiology and Nuclear Medicine, Fukushima Medical University, Fukushima, Japan. kfukush4@fmu.ac.jp.
Masataka KatahiraDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Naoyuki UkonAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima, Japan.
Ryo YamakuniDepartment of Radiology and Nuclear Medicine, Fukushima Medical University, Fukushima, Japan.
Joh AkamaDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Takeshi ShimizuDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Takatoyo KikoDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Shiro IshiiDepartment of Radiology and Nuclear Medicine, Fukushima Medical University, Fukushima, Japan.
Masayoshi OikawaDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Hiroshi ItoDepartment of Radiology and Nuclear Medicine, Fukushima Medical University, Fukushima, Japan.
Yasuchika TakeishiDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the correlation and assess the interchangeability between myocardial flow reserve (MFR) quantified by positron emission tomography (PET) and coronary sinus flow (CSF) reserve measured by cardiac magnetic resonance (CMR) in patients with ischemic heart disease, utilizing a hybrid PET/MR system.

methodsConsecutive 119 patients (mean 68.5 ± 13.1ys, male 95) who underwent rest-pharmacological stress

resultsRest and stress CSF showed a significant but weak correlation to MBF (r = 0.40, p < 0.0001; r = 0.44, p < 0.0001 for rest and stress, respectively). CSF reserve showed a significant but moderate correlation with MFR (r = 0.43, p < 0.0001) and a weak inverse correlation with SSS (r = - 0.27, p = 0.003). Brand-Altman plots revealed a poor agreement with a proportional error (bias - 0.60 ± 1.34, 95%limit of agreement - 2.02 to 3.21).

conclusionDespite a moderate correlation, CSF reserve and PET-derived MFR demonstrate poor agreement and are not interchangeable. The divergence between these metrics necessitates caution when interpreting global coronary flow reserve derived from CMR in patients with established ischemic heart disease.

Indexed as

AmmoniaCoronary CirculationCoronary SinusFractional Flow Reserve, MyocardialMagnetic Resonance Imaging, CineMultimodal ImagingMyocardial IschemiaMyocardial Perfusion ImagingNitrogen RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsAgedBlood Flow VelocityFemaleHumansMaleAmmoniaNitrogen-13Nitrogen RadioisotopesRadiopharmaceuticalsCardiac magnetic resonanceCoronary sinus flowIschemic heart diseaseMyocardial flow reservePositron emission tomography

Identifiers

PMID41144174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.