Evidence map›Paper›PMID 41144120›Full record

ArticleCurrent medical science2025

Association Between the Uric Acid to High-Density Lipoprotein Ratio and Carotid Atherosclerosis in Patients with T2DM.

Yao Yin, Zi-Yun Feng, Li-Yin Zhang, Jiao-Yue Zhang, Si Jin

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Article in Current medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yao YinDepartment of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.ORCID http://orcid.org/0009-0006-5780-0959
Zi-Yun FengDepartment of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
Li-Yin ZhangDepartment of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
Jiao-Yue ZhangDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. zhangjiaoyue@126.com.
Si JinDepartment of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China. JinSi@hust.edu.cn.

Funding

National Natural Science Foundation of China No. 82070862National Natural Science Foundation of China No.82370840the National Key R&D Program of China No. 2020YFC2008900
6 · The paper itself

Abstract

objectiveUric acid (UA) to high-density lipoprotein (HDL) ratio (UHR) has recently been proposed as a novel biomarker of inflammation. This study aimed to investigate the association between the UHR and carotid atherosclerosis (CAS) in patients with type 2 diabetes mellitus (T2DM).

methodsIn this single-center, retrospective cross-sectional study, 379 patients with T2DM were enrolled and categorized into two groups: 259 T2DM patients with CAS (T2DM-CAS) and 120 T2DM patients without CAS (T2DM-WCAS). Carotid intima‒media thickness (CIMT) and carotid atheromatous plaques (CAPs) were assessed via Doppler ultrasound. UHR values were compared between the groups, and receiver operating characteristic (ROC) curve analysis was employed to evaluate their diagnostic performance.

resultsThe UHR was significantly greater in the T2DM-CAS group than in the T2DM-WCAS group (P < 0.001). Multivariate logistic regression analysis identified the UHR as an independent risk factor for T2DM-CAS (P < 0.001). The area under the ROC curve (AUC) for UHR to detect CAS was 0.750, with an optimal cut-off value of 0.35.

conclusionThe UHR is an independent risk factor for CAS in patients with T2DM and may serve as a valuable biomarker for predicting CAS in this population.

Indexed as

Carotid Artery DiseasesDiabetes Mellitus, Type 2Lipoproteins, HDLUric AcidAgedBiomarkersCarotid Intima-Media ThicknessCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsROC CurveBiomarkersLipoproteins, HDLUric AcidBiomarkerCardiovascular riskCarotid atheromatous plaqueCarotid atherosclerosisCarotid intima–media thicknessType 2 diabetes mellitus (T2DM)Uric acid to high-density lipoprotein ratio (UHR)

Identifiers

PMID41144120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.