Trial reportClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Integrated sleep and psychological interventions enhance postoperative recovery and quality of life in colorectal cancer: a randomized controlled trial.
Trial report in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Circadian Rhythms in Colorectal Cancer: Recent Advances in Development and Treatment.Journal of clinical medicine research · 2026Review
- Longitudinal trajectories of cancer-related cognitive impairment and influential factors among patients with lung cancer.Comprehensive psychoneuroendocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with colorectal cancer frequently experience sleep disturbance, psychological distress, and impaired quality of life after surgery. These symptoms are interrelated through inflammatory and neuroendocrine pathways but are rarely addressed using integrated interventions.
methodsWe conducted a prospective, single-center randomized controlled trial at the First Affiliated Hospital of Soochow University (September 2021-September 2023). A total of 300 patients with stage I-III colorectal cancer were randomized (1:1) to standard oncological care or to a combined intervention including sleep hygiene education, relaxation training, stimulus control, and cognitive-behavioral therapy-based psychological support. Outcomes included Pittsburgh Sleep Quality Index (PSQI), Visual Analog Scale (VAS) pain, Zung Anxiety (SAS) and Depression (SDS) scales, and EORTC QLQ-C30 Global Health/Quality of Life (GHS/QL). Analyses followed the intention-to-treat principle, with multiple imputation for missing data and analysis of covariance (ANCOVA) adjusted for baseline scores.
resultsOf 356 patients screened, 300 were randomized (150 per group). At 3 months, the intervention group showed greater improvement in PSQI (aMD - 7.5, 95% CI - 8.4 to - 6.6, p < 0.001), VAS pain (aMD - 3.2, 95% CI - 3.6 to - 2.8, p < 0.001), SAS (aMD - 13.2, 95% CI - 14.7 to - 11.7, p < 0.001), and SDS (aMD - 13.5, 95% CI - 15.1 to - 12.0, p < 0.001). Global quality of life improved significantly (aMD + 12.5, 95% CI + 10.9 to + 14.1, p < 0.001). All changes exceeded minimal clinically important differences. Intervention adherence was high (93.3%), and no adverse events occurred.
conclusionAn integrated program of sleep and psychological interventions produced clinically and statistically significant improvements in postoperative sleep quality, pain, anxiety, depression, and overall quality of life in colorectal cancer patients. This safe, feasible, and replicable strategy may complement enhanced recovery after surgery (ERAS) protocols and warrants multicenter evaluation with extended follow-up.
Indexed as
Identifiers
41144100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.