ArticleJournal of gastrointestinal cancer2025
Impact of Age and Comorbidities On Therapeutic Decision-making Among Older Patients With Gastrointestinal Cancer.
Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Neoplastic Disorders and Cardiovascular Comorbidities in Geriatric Patients: A Simple Association?Geriatrics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe impact of age, comorbidities and geriatric syndromes is often overlooked during tumor board (TB) decisions. We investigated how frequently age, comorbidities, functional and nutritional parameters, and frailty are mentioned when deciding treatments for older adults with gastrointestinal (GI) cancers, and the impact these variables have on adherence to TB decisions and treatment guidelines from the European Society for Medical Oncology (ESMO).
methodsCross-sectional study of data from patients aged ≥ 65 years presented before the GI-TB of a tertiary cancer center between July 2019 and December 2022 based on electronic health records and TB documentation. Mention of age, comorbidity, functional and nutritional parameters, and frailty at decision-making, and adherence to TB decisions and treatment guidelines were assessed.
results418 patients with a mean age of 77 years and Charlson Comorbidity Index (CCI) of 8.6 were included. Geriatric variables were mentioned in 43.8% of cases. Among these, comorbidities were mentioned in 17.2%, whereas age was mentioned in 14.6%. Adherence to TB decisions was 82%, whereas adherence to ESMO guidelines was 69%. Mention of age and comorbidity was associated with a 2-fold and 3-fold reduction in the likelihood of adherence to ESMO guidelines (p = 0.02 and 0.001, respectively). This association was not found when analysing adherence to TB decisions.
conclusionsGeriatric variables, despite being often neglected at the time of defining treatment for the older adult with cancer, can have an effect on oncologic decision-making. Our findings underscore the need for integrating assessment of geriatric variables into oncologic care to support individualized, guideline-concordant treatment planning that reflects the complexity and needs of this population.
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