Evidence map›Paper›PMID 41144063›Full record

ArticleBrain structure & function2025

On handedness and the lateralization of fusiform face area(s).

Ruilin Zhang, Xinmiao Yuan, Youyi Liu, Zonglei Zhen, Kevin Sean Weiner

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Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Faces and Word Forms Can Coexist in the Right Ventro-occipital Temporal Cortex-Evidence from Left-Hemisphere Perinatal Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruilin Zhang *State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Xinmiao Yuan *Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Youyi LiuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Zonglei ZhenState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. zhenzonglei@bnu.edu.cn.
Kevin Sean WeinerHelen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720, USA.

Funding

NSF (National Science Foundation) 2042251STI 2030-Major Projects 2021ZD0200500
6 · The paper itself

Abstract

In the human cerebral cortex, the right hemisphere dominance of face processing has been well-established across age groups and in different clinical populations. Nevertheless, the role of handedness in this lateralization remains unclear as previous studies have yielded inconclusive results due to small sample sizes and the fact that they did not consider recent results identifying multiple face-selective regions on the fusiform gyrus (FG) that are anatomically and functionally distinct in over 1000 individuals. To address these parallel concerns, we investigated the relationship between handedness and the structural, functional, and connectivity properties of manually defined FG face-selective regions using multimodal neuroimaging data from a large sample of non-right-handers (N = 124)—a sample size which is 5–11 times the size of previous studies. Our careful, manual delineations of FG face-selective regions—in the spirit of “precision imaging” in the broader cognitive neuroscience and human brain mapping fields—revealed that pFus-faces/FFA-1 is more selective in the right, compared to the left, hemisphere in non-right handers, which is not the case for mFus-faces/FFA-2. Subsequent analyses relating handedness to network properties or anatomical features did not reveal any significant effects. The combination of these findings provides a foundation for implementing a precision imaging approach that is ideal for building strategies for case studies and the treatment and intervention of neurological disorders that include issues with either face perception, handedness, or both—as well as evolutionary and theoretical insights regarding hemispheric specialization of cortical function.

Indexed as

Facial RecognitionFunctional LateralityTemporal LobeAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleYoung AdultFusiform face area(s)HandednessLateralizationMultimodal magnetic resonance imagingPrecision imaging

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.