Evidence map›Paper›PMID 41144046›Full record

SynthesisNeurosurgical review2025

Determinants of diagnostic accuracy and therapeutic outcomes of SEEG in epilepsy: a systematic review.

David F Estupiñan-Pepinosa, Maria F Cordoba-Gallego, Juan P Quintero-Ruiz, Nikolas Correa-Molina, Paola A Niño-Muñoz, Juan S Aguirre-Patiño, Cesar A Buitrago, Luis C Mayor-Romero, Paula Martinez-Micolta, Jheremy S Reyes

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David F Estupiñan-PepinosaUniversidad de Los Andes, Bogotá, D.C., Colombia. d.estupinanp@uniandes.edu.co.
Maria F Cordoba-GallegoUniversidad de Los Andes, Bogotá, D.C., Colombia.
Juan P Quintero-RuizUniversidad de Los Andes, Bogotá, D.C., Colombia.
Nikolas Correa-MolinaUniversidad de Los Andes, Bogotá, D.C., Colombia.
Paola A Niño-MuñozUniversidad de Los Andes, Bogotá, D.C., Colombia.
Juan S Aguirre-PatiñoDepartment of Neurology, Epilepsy Clinic, Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.
Cesar A BuitragoDepartment of Neurology, Epilepsy Clinic, Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.
Luis C Mayor-RomeroDepartment of Neurology, Epilepsy Clinic, Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.
Paula Martinez-MicoltaUniversidad de Los Andes, Bogotá, D.C., Colombia.
Jheremy S ReyesCancer and Molecular Medicine Research Group (CAMMO), Bogotá, D.C., Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereoelectroencephalography (SEEG) is a cornerstone in the presurgical evaluation of drug-resistant focal epilepsy. Despite its growing adoption, variability in outcomes and complication rates suggests the influence of multiple technical, institutional, and contextual factors. A systematic review was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420251065875). Six databases were searched up to July 2024. Eligible studies included original research in English or Spanish reporting on SEEG procedures in patients with drug-resistant epilepsy, with outcomes related to diagnostic accuracy, complications, and therapeutic interventions. Data were extracted and synthesized narratively across five thematic domains. Fifty studies involving 6,054 patients were included. Most were retrospective and conducted in high-income countries. Epileptogenic zone (EZ) identification rates ranged from 11.6% to 100%, with over 30 studies reporting rates ≥ 90%. A total of 465 SEEG-related complications were reported, predominantly intracranial hemorrhages. Lower complication rates were observed in high-volume centers using robotic or frame-based systems. Post-SEEG interventions, primarily surgical resections, led to favorable outcomes, with Engel Class I achieved in 551 patients. Institutional experience and access to advanced technologies emerged as key determinants of safety and efficacy. SEEG is a highly effective diagnostic and therapeutic modality in epilepsy surgery. However, its performance is strongly influenced by surgical expertise, procedural planning, and institutional context. Standardizing protocols, expanding training, and improving access in underserved regions are essential to optimize outcomes and ensure equitable care.

Indexed as

Drug Resistant EpilepsyElectroencephalographyEpilepsyStereotaxic TechniquesHumansNeurosurgical ProceduresTreatment OutcomeDiagnostic accuracyDrug-resistant epilepsyEpilepsy surgeryNeurosurgical outcomesStereoelectroencephalography

Identifiers

PMID41144046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.