Immunoglobulin genetics of a model squamate reptile, Tiliqua rugosa.

Jordan M Sampson, Kieran J Mikolajova, Michael G Gardner, Terry Bertozzi, Robert D Miller

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Article in Immunogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Jordan M SampsonCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA.ORCID 0000-0002-1065-5292

Kieran J MikolajovaCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA.

Michael G GardnerCollege of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0002-8629-354X

Terry BertozziSouth Australian Museum, Adelaide, South Australia, Australia.ORCID 0000-0001-6665-3395

Robert D MillerCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA. rdmiller@unm.edu.ORCID 0000-0002-8479-8819

Funding

Australian Research Council DP200102880National Science Foundation IOS-2103367

6 · The paper itself

Abstract

Squamate reptiles are a diverse group of terrestrial vertebrates that includes over 10,000 species. Despite their broad distribution, they are relatively understudied immunologically. Fortunately, recent advances in comparative genomics have facilitated studies of squamate immune systems, revealing their unique features. For example, squamates lack of γδ T cells entirely due to genomic deletions. Here we annotated and analyzed the loci encoding the Tiliqua rugosa immunoglobulin heavy and lambda light chains, revealing a remarkably large and complex number of variable region genes in both. Tiliqua rugosa lacks genes encoding a kappa light chain, which can be found in some but not all squamates. We also identified common reptile IgH isotypes including IgM, IgD, and IgY, but no IgA. Overall, T. rugosa, has the germline capability of generating a highly diverse antibody repertoire.

Indexed as

ImmunoglobulinsLizardsReptilesAnimalsImmunoglobulin Heavy ChainsImmunoglobulin lambda-ChainsImmunoglobulin Variable RegionPhylogenyImmunoglobulin Heavy ChainsImmunoglobulin lambda-ChainsImmunoglobulinsImmunoglobulin Variable RegionAntibody repertoireGenomicsImmunoglobulinsSquamate reptiles

Identifiers

PMID41144012

DOI10.1242/jeb.038315

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