Evidence map›Paper›PMID 41144010›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2025

Oral citral attenuates alveolar bone loss and inflammation in ligature-induced periodontitis in rats.

Wanderson S Santos, Isabelly G Solon, Pedro H Lopes, Glauce C Nascimento, Luiz G S Branco

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Wanderson S SantosDepartment of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of São Paulo, Avenida Do Cafe S/N, Ribeirão Preto, SP, 14040-904, Brazil.
Isabelly G SolonDepartment of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of São Paulo, Avenida Do Cafe S/N, Ribeirão Preto, SP, 14040-904, Brazil.
Pedro H LopesDepartment of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of São Paulo, Avenida Do Cafe S/N, Ribeirão Preto, SP, 14040-904, Brazil.
Glauce C NascimentoDepartment of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of São Paulo, Avenida Do Cafe S/N, Ribeirão Preto, SP, 14040-904, Brazil.
Luiz G S BrancoDepartment of Basic and Oral Biology, Ribeirao Preto School of Dentistry, University of São Paulo, Avenida Do Cafe S/N, Ribeirão Preto, SP, 14040-904, Brazil. branco@forp.usp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303594/2024-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Open Access Agreement with CAPES/BrazilFundação de Amparo à Pesquisa do Estado de São Paulo 2023/08395-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/14005-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/14676-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/03285-0
6 · The paper itself

Abstract

backgroundIn a ligature-induced periodontitis rat model, we tested oral citral (100 mg/kg, gavage) for 6 or 14 days and quantified alveolar bone loss, gingival cytokines, nitric oxide (NO), reactive oxygen species (ROS), MMP-2 activity, and plasma TNF-α.

methodsAdult male rats received a ligature around the first lower right molar for 7 or 15 days to induce periodontitis, while control animals remained unligated. Alveolar bone loss was assessed by measuring the cementoenamel junction-bone crest distance. Gingival cytokines (TNF-α, IL-1β, IL-6, IL-10) and plasma TNF-α were determined by ELISA, gingival NO by chemiluminescence, MMP-2 activity by gelatin zymography, and local ROS by in situ detection.

resultsCitral did not affect healthy gingiva. In ligature-induced periodontitis, a 14-day citral treatment significantly reduced alveolar bone loss, downregulated pro-inflammatory cytokines, increased IL-10, decreased plasma TNF-α levels, and inhibited both NO production and MMP-2 activity. ROS accumulation in the gingival tissue was also attenuated.

conclusionThese findings suggest that oral citral exhibits anti-inflammatory and antioxidant effects, thereby limiting alveolar bone loss in experimental periodontitis.

Indexed as

Alveolar Bone LossAnti-Inflammatory AgentsMonoterpenesPeriodontitisAcyclic MonoterpenesAdministration, OralAnimalsCytokinesGingivaInflammationLigationMaleMatrix Metalloproteinase 2Nitric OxideRatsRats, WistarAcyclic MonoterpenesAnti-Inflammatory AgentscitralCytokinesMatrix Metalloproteinase 2MonoterpenesNitric OxideReactive Oxygen SpeciesTumor Necrosis Factor-alphaCytokineGingivaInflammationMatrix metalloproteinasesNitric OxideRat

Identifiers

PMID41144010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.