Childhood-Onset Psychosis: A large UK case series.

Mitra S Sato, Anthony James, Marinos Kyriakopoulos, Anna C Need

Abstract read

In one paragraph

Article in European child & adolescent psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Medical workup in pediatric first psychotic presentation: real-world diagnostic utility in a large tertiary cohort.European child & adolescent psychiatry · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mitra S SatoFaculty of Medicine, Department of Brain Sciences, Imperial College London, Du Cane Road, London, UK.

Anthony JamesDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.

Marinos Kyriakopoulos1st Department of Psychiatry, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.

Anna C NeedFaculty of Medicine, Department of Brain Sciences, Imperial College London, Du Cane Road, London, UK. a.need@imperial.ac.uk.

Funding

Marie Curie Integration Grant CIG 631787

6 · The paper itself

Abstract

Childhood-Onset Psychosis (COP) is an extremely rare and severe variant of psychosis. This paper presents the largest UK case series of COP, comprising 39 families (105 individuals) recruited between 2016 and 2019. It is also the most ethnically diverse collection of COP cases worldwide, with 36% European ancestry, 23% South Asian, 18% African, 10% Mixed ancestry and 13% Other. All probands were hospitalised and diagnosed with a psychotic disorder by age 13, including schizoaffective disorder, paranoid schizophrenia, childhood-onset schizophrenia and other nonorganic psychotic disorders. The cohort had a male-to-female ratio of 1:1.4, with females diagnosed at a higher mean age (11 years 9 months) than males (10 years 6 months). While 54% of probands had no reported first-degree family history of mental disorders, 59% presented with comorbid neurodevelopmental conditions. Approximately one-third were treated with clozapine, reflecting the severity and treatment resistance of the cases.

Indexed as

Psychotic DisordersSchizophrenia, ChildhoodAdolescentAge of OnsetAntipsychotic AgentsChildComorbidityFemaleHumansMaleUnited KingdomAntipsychotic AgentsChildhood onset psychosis (COP)Childhood onset schizophrenia (COS)Comorbid neurodevelopmental disordersEthnically diverseTreatment resistantVery early onset psychosis (VEOP)

Identifiers

PMID41144000

DOI10.1007/s00787-025-02895-3

PMCPMC13212701

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