ArticleEuropean journal of nuclear medicine and molecular imaging2026
Optimizing uPAR-targeting radiopeptides for improved tissue distribution: progress towards radionuclide therapy.
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe aim of this study was to develop radiopeptides for targeting the urokinase-type plasminogen activator receptor (uPAR) modified with an albumin-binding moiety to improve their tissue distribution profiles.
methodsuPAR-11, uPAR-12, uPAR-14, uPAR-15, uPAR-17 and uPAR-18 were synthesized based on the AE105 nonapeptide which was modified with the p-tolyl-based albumin binder and variable linker entities and chelators. The
resultsThe radiopeptides showed 11‒155-fold higher albumin-binding affinity in human blood plasma than [
conclusionIn view of a clinical translation, [
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