Evidence map›Paper›PMID 41143947›Full record

ArticleInternational journal of hematology2026

Novel noninvasive parameters for diagnosis of liver involvement in patients with systemic AL amyloidosis.

Ryohei Sumitani, Hirokazu Miki, Shingen Nakamura, Masafumi Nakamura, Taiki Hori, Yusaku Maeda, Masahiro Oura, Kimiko Sogabe, Hikaru Yagi, Mamiko Takahashi and 7 more

Abstract read
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Article in International journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Ryohei Sumitani *Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Hirokazu Miki *Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima, 770-8503, Japan. mikihiro@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0002-3437-5332
Shingen Nakamura *Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Masafumi NakamuraDepartment of Internal Medicine, Tokushima Prefectural Naruto Hospital, Tokushima, Japan.
Taiki HoriDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Yusaku MaedaDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Masahiro OuraDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Kimiko SogabeDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Hikaru YagiDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Mamiko TakahashiDepartment of Hematology, Kawashima Hospital, Tokushima, Japan.
Takeshi HaradaDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Shiro FujiiDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Naoto OkadaPharmacy Department, Yamaguchi University Hospital, Yamaguchi, Japan.
Susumu NishioUltrasound Examination Center, Tokushima University Hospital, Tokushima, Japan.
Tetsu TomonariDepartment of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Masahiro AbeDepartment of Hematology, Kawashima Hospital, Tokushima, Japan.
Ken-Ichi MatsuokaDepartment of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.

Funding

Health Labour Sciences Research Grant 23FC1035Japanese Society of Hematology 20289Japanese Society of Hematology 24155JSPS KAKENHI JP20K08712
6 · The paper itself

Abstract

Liver involvement in systemic immunoglobulin light-chain (AL) amyloidosis is diagnosed by an increase in liver size and/or elevated serum alkaline phosphatase (ALP) levels. However, novel diagnostic approaches that reflect the organ-specific characteristics of liver involvement are needed. Shear wave elastography (SWE) is a noninvasive and repeatable technique for measuring tissue stiffness. In this study, we evaluated the clinical significance of SWE and serum biochemistry tests in the diagnosis of AL amyloidosis with liver involvement. Twenty-five patients with systemic AL amyloidosis were examined. Eight patients were diagnosed with liver involvement according to the current consensus criteria. In patients with and without liver involvement, hepatic shear wave velocity (SWV) was 1.93 ± 0.39 versus 1.36 ± 0.11 m/sec (p = 0.00099), and the gamma-glutamyltranspeptidase (γ-GTP) level was 165 ± 131 versus 36 ± 28 U/L (p = 0.00222). Receiver-operating characteristic curve analysis showed that SWV and γ-GTP levels had favorable diagnostic accuracy for liver involvement. Of note, two patients with liver involvement who achieved organ response showed a decrease in both SWV and γ-GTP levels. These results suggest that SWV and γ-GTP are useful for establishing accurate organ-specific diagnosis and response criteria for liver involvement in AL amyloidosis.

Indexed as

Elasticity Imaging TechniquesImmunoglobulin Light-chain AmyloidosisLiverLiver DiseasesAdultAgedFemalegamma-GlutamyltransferaseHumansMaleMiddle AgedROC Curvegamma-GlutamyltransferaseAL amyloidosisLiver involvementShear wave velocityUltrasound shear wave elastographyγ-GTP

Identifiers

PMID41143947

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.