ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Paclitaxel-coated balloon with urea or iopromide as the excipient for treatment of coronary artery disease.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Routine versus selective use of a femoral protection wire in transfemoral TAVI: a single-centre analysis of vascular complications.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Performance of a sirolimus-eluting balloon with phospholipid nanocarriers in the treatment of long de novo coronary artery disease: the prospective GINGER trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Performance of a sirolimus-eluting balloon with phospholipid nanocarriers in the treatment of long de novo coronary artery disease: the prospective GINGER trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- A novel sirolimus-coated balloon versus a paclitaxel-coated balloon for coronary artery disease: the SELSEQ registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Paclitaxel-coated balloon with urea or iopromide as the excipient for treatment of coronary artery disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
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Authors and funding
15 authors.
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Abstract
backgroundDrug-coated balloons (DCBs) are increasingly used to treat coronary artery disease, and their safety and efficacy profile can vary based on the eluted drug and excipient. Head-to-head comparisons of paclitaxel-coated balloons (PCBs) according to contemporary excipient formulations are scant.
methodsConsecutive patients undergoing DCB angioplasty with either urea PCB (Prevail, Medtronic, Dublin, Ireland) or iopromide PCB (Sequent Please / NEO, B. Braun, Melsungen, Germany) at two Italian institutions from 2021 to 2024 were retrospectively enrolled. The primary endpoint was target lesion failure (TLF), a composite including target lesion revascularization, target vessel myocardial infarction, and cardiac death, at 1 year. Clinical endpoints were compared through propensity score adjustment for clinical and angiographic variables.
resultsA total of 448 patients were included, with 211 patients (240 lesions) treated with urea PCB and 237 patients (287 lesions) treated with iopromide PCB. The prevalence of in-stent restenosis (ISR) was 30% in the urea PCB group and 23% in the iopromide PCB (p = 0.070). At 1 year, the cumulative incidence of TLF was 8.1% in both groups (adjusted hazard ratio (HR): 0.90, 95% CI: 0.27-3.00). Rates of secondary endpoints were also similar. Subgroup analyses showed no significant interaction between treatment groups and any of the prespecified subgroups, including lesion type (de novo vs. in-stent restenosis; p
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