Evidence map›Paper›PMID 41143887›Full record

ArticleLangenbeck's archives of surgery2025

Long-term outcomes of minimally invasive esophagectomy vs. open esophagectomy in older patients with esophageal squamous cell carcinoma: a propensity score matching analysis.

Kexun Li, Simiao Lu, Changding Li, Jie Mao, Huan Zhang, Kangning Wang, Guangyuan Liu, Yongtao Han, Lin Peng, Xuefeng Leng

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kexun LiDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China.
Simiao LuDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China.
Changding LiDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China.
Jie MaoDepartment of Thoracic Surgery I, Key Laboratory of Lung Cancer of Yunnan Province, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital, Kunming, China.
Huan ZhangDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China.
Kangning WangDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China.
Guangyuan LiuDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China.
Yongtao HanDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China.
Lin PengDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China. penglinms@126.com.
Xuefeng LengDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Sichuan Cancer Hospital, No. 55, Section 4, South Renmin Road, Chengdu, 610041, China. doc.leng@uestc.edu.cn.

Funding

Chengdu Science and Technology Bureau Key Research Project 2024-YF05-00797-SNDoctoral Student Educational Innovation Fund Project of Kunming Medical University 2025B014International Cooperation Projects of the Science and Technology Department of Sichuan Province 2024YFHZ0322National Key Research and Development Program 2022YFC2403400National Natural Science Foundation of China 82472663Sichuan Key Research and Development Project from the Science and Technology Department of Sichuan Province 2023YFS0044Sichuan Province Clinical Key Specialty Construction Project [2022]70Wu Jieping Clinical Research Projects 320.6750.2023-05-141
6 · The paper itself

Abstract

objectiveEsophageal squamous cell carcinoma (ESCC) remains a significant health concern, particularly among older patients. While both minimally invasive esophagectomy (MIE) and open esophagectomy (OE) are established surgical types, there is ongoing debate about their comparative long-term outcomes in older patients.

methodsThis retrospective cohort study analyzed data from 469 patients with ESCC aged over 70 years who underwent esophagectomy between May 2016 and August 2021. Patients were divided into MIE and OE groups. Overall survival (OS), disease-free survival (DFS), and postoperative complications were evaluated. Propensity score matching was performed to minimize selection bias. Complications were assessed using the Clavien-Dindo classification system.

resultsAmong 469 patients, 358 (76.33%) underwent MIE, while 111 (23.67%) underwent OE. After a median follow-up of 47.5 months, the MIE group had significantly better OS (median OS: 60.17 vs. 29.18 months, HR = 1.566, P = 0.002) and DFS (median DFS: 37.70 vs. 25.20 months, HR = 1.411, P = 0.010) compared to the OE group. After PSM, MIE remained associated with significantly improved OS (HR = 1.450, P = 0.039), while the difference in DFS was no longer significant (HR = 1.240, P = 0.201). The incidence of Clavien-Dindo grade III-IV complications was similar between groups.

conclusionMIE is associated with better long-term survival outcomes compared to OE in older patients with ESCC, without increasing major postoperative complications. These findings support the consideration of MIE as a preferred surgical approach for older patients with ESCC to enhance survival and optimize postoperative recovery.

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyMinimally Invasive Surgical ProceduresAgedAged, 80 and overFemaleHumansMalePostoperative ComplicationsPropensity ScoreRetrospective StudiesSurvival RateTreatment OutcomeMinimally Invasive EsophagectomyOlder patientsOpen EsophagectomyOverall SurvivalPostoperative complications

Identifiers

PMID41143887
PMCPMC12559150

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.