Evidence map›Paper›PMID 41143874›Full record

ArticleAnnals of medicine2025

Lactate combined with lymphocyte counts as useful predictors for the severity and prognosis of necrotizing enterocolitis: a retrospective cohort study.

Dabin Huang, Yuying Lin, Yueju Cai, Zhihui Chen, Zhenyu Liang, Xiaowen Chen, Heng Su, Mou Wei, Qiong Meng, Wei Zhou

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In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Dabin HuangDepartment of Pediatrics, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yuying LinDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Yueju CaiDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zhihui ChenDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zhenyu LiangDepartment of Pediatrics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Xiaowen ChenDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Heng SuDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Mou WeiDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Qiong MengDepartment of Pediatrics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Wei ZhouDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) lacks useful biomarkers for early risk stratification. Despite evidence of lactate metabolism and immune dysregulation in NEC pathogenesis, their synergistic diagnostic potential remains underexplored.

methodThis retrospective cohort study analyzed 118 neonates with NEC (2017-2022), stratified into two subgroups: mild NEC (Bell's stage ≤ IIa,

resultsSevere NEC exhibited significantly lower lymphocytes (1.58 vs. 3.71 × 10

conclusionCombined lactate and lymphocytes enhance risk stratification and prognostic accuracy in NEC, bridge metabolic and immune pathways, and offer clinical utility for guiding early interventions in high-risk neonates with NEC.

Indexed as

Enterocolitis, NecrotizingLactic AcidBiomarkersFemaleHumansInfant, NewbornInfant, PrematureLymphocyte CountMalePredictive Value of TestsPrognosisRespiration, ArtificialRetrospective StudiesSeverity of Illness IndexBiomarkersLactic AcidbiomarkerslactatelymphocytesmortalityNecrotizing enterocolitis

Identifiers

PMID41143874
PMCPMC12570253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.