Evidence map›Paper›PMID 41143657›Full record

ArticleJournal of the American Chemical Society2025

Alexander M Hoffnagle, Ryan A Herold, Chia-Ying Tsai, Angela A Shiau, R David Britt, F Akif Tezcan

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander M HoffnagleUniversity of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-4840-312X
Ryan A HeroldUniversity of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0001-7935-6269
Chia-Ying TsaiUniversity of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, La Jolla, California 92093, United States.
Angela A ShiauUniversity of California, Davis, Department of Chemistry, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0003-4395-9847
R David BrittUniversity of California, Davis, Department of Chemistry, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0003-0889-8436
F Akif TezcanUniversity of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-4733-6500

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Jay C. Nix · 2017 to 2026
$28.6M
MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Design and Evolution of Metal-Based Functions in Supramolecular Protein ScaffoldsR01GM138884 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TEZCAN, F. AKIF · 2020 to 2025
$2.0M
Spectroscopic Characterization of Enzymatic Intermediates with FeS ClustersF32GM157846 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Angela Shiau · 2025 to 2026
$152k
NIGMS NIH HHS F32 GM157846NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM138884NIGMS NIH HHS R35 GM126961NIGMS NIH HHS T32 GM008326
6 · The paper itself

Abstract

A metal-centered design approach was used to design a tetrameric protein assembly, PW1, with a new-to-nature metal center inspired by the structures of transition metal paddlewheel complexes such as di-Cu

Identifiers

PMID41143657
PMCPMC13682728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.