Trial reportJournal of the National Cancer Institute2026
Electro-acupuncture for quality of life during adjuvant chemotherapy in gastric cancer: a randomized trial.
Trial report in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04360577 (Effect of Acupuncture for Quality of Life and Symptom Control in Patients With Gastric Cancer Undergoing Adjuvant Chemotherapy), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Acupuncture for Quality of Life and Symptom Control in Patients With Gastric Cancer Undergoing Adjuvant Chemotherapy
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
Abstract
backgroundPatients with locally advanced gastric cancer who undergo curative intent gastrectomy experience a decline in health-related quality of life (HRQOL) during adjuvant chemotherapy. The Electro-Acupuncture in Gastric Cancer (EAGER) trial sought to evaluate the ability of electro-acupuncture to preserve HRQOL in these patients.
methodsIn this open-label, multicenter, parallel controlled trial, patients with stage II-III gastric cancer across 11 hospitals in China who were undergoing chemotherapy following gastrectomy were randomly assigned to receive high-frequency electro-acupuncture, low-frequency electro-acupuncture, or no electro-acupuncture during the first 3 cycles of chemotherapy. The Functional Assessment of Cancer Therapy-Gastric was reported by patients at baseline and once weekly during the therapy. The primary outcome was the difference among groups in the Functional Assessment of Cancer Therapy-Gastric Trial Outcome Index trajectory during the study duration by the standardized area under the curve.
resultsOf 222 patients randomly assigned and analyzed, electro-acupuncture was associated with higher HRQOL measured by Trial Outcome Index-area under the curve (mean ± SD = 5678 ± 1229 [high-frequency electro-acupuncture], 5558 ± 1226 [low-frequency electro-acupuncture], and 4735 ± 1233 [usual care]; P < .001). No difference was seen based on acupuncture dosing (P = .557). Participants in the electro-acupuncture groups also showed a statistically significant improvement in disease-free survival (high-frequency electro-acupuncture vs usual care: hazard ratio [HR] = 0.47, 95% confidence interval [CI] =0.24 to 0.93; P = .026; low-frequency electro-acupuncture vs usual care: HR = 0.51, 95% CI = 0.28 to 0.95; P = .030), fewer grade 3-4 adverse events (20.7% vs 39.0%, P = .004), and decreased peripheral myeloid-derived suppressor cells (P = .038) compared with the usual care group.
conclusionsUse of electro-acupuncture resulted in higher HRQOL in gastric cancer patients undergoing adjuvant chemotherapy, irrespective of dosing. Electro-acupuncture was also associated with prolonged disease-free survival and lower treatment-associated toxicities, which warrants further confirmative research.
trial registrationClinicalTrials.gov NCT04360577.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.