Evidence map›Paper›PMID 41143495›Full record

Trial reportFood & function2025

Serum proteins associated with LDL-C and non-HDL-C reduction in response to dietary interventions in the DASH and DASH-Sodium trials.

Hyunju Kim, Alice H Lichtenstein, Josef Coresh, Lawrence J Appel, Casey M Rebholz

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Food & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyunju KimDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Alice H LichtensteinJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Josef CoreshDepartment of Population Health, New York University, New York, New York, USA.
Lawrence J AppelDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA. crebhol1@jhu.edu.
Casey M RebholzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA. crebhol1@jhu.edu.ORCID http://orcid.org/0000-0002-5442-8745

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 1985 to 2008
$48.4M
Discovery, Replication, and Validation of Biomarkers of the DASH Diet and HypertensionR01HL153178 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI REBHOLZ, CASEY MARIE · 2021 to 2024
$3.1M
Proteomic and epigenetic alterations associated with plant-based diets and CVDK01HL168232 · NHLBI · UNIVERSITY OF WASHINGTON · PI Hyunju Kim · 2023 to 2026
$683k
DIETARY PATTERNS, SODIUM INTAKE, AND BLOOD PRESSUREU01HL057114 · NHLBI · DUKE UNIVERSITY · PI SVETKEY, LAURA P · 1997 to 2000
$159k
ZIDOVUDINE WITH PROBENECID--EFFECTS OF PROBENECID ON ZIDOVUDINEM01RR000722 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MILLER, EDWARD D · 1985 to 1996
–
NCRR NIH HHS M01 RR000722NCRR NIH HHS M01 RR002635NHLBI NIH HHS K01 HL168232NHLBI NIH HHS R01 HL153178NHLBI NIH HHS U01 HL057114
6 · The paper itself

Abstract

The Dietary Approaches to Stop Hypertension (DASH) diet reduced low-density lipoprotein (LDL)-cholesterol (C) and non-high-density lipoprotein (HDL)-C levels compared to the control diet. However, the mechanisms underlying the relation between the DASH diet and lipoprotein levels are not fully understood. We identified DASH diet-related proteins that were differently associated with LDL-C and non-HDL-C in two randomized controlled feeding studies comparing a DASH to control diet (DASH and DASH-Sodium trials). Two proteins [collagen triple helix repeat-containing protein 1 (CTHRC1) and growth differentiation factor 8 (MSTN)], and one protein [phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL)], were differentially associated with changes in LDL-C and non-HDL-C, respectively, in the DASH and DASH-Sodium trials (

Indexed as

Blood ProteinsCholesterol, HDLCholesterol, LDLDietary Approaches To Stop HypertensionHypertensionAdultAgedFemaleHumansMaleMiddle AgedBlood ProteinsCholesterol, HDLCholesterol, LDL

Identifiers

PMID41143495
PMCPMC12558031

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.