ArticleInvestigative ophthalmology & visual science2025
Total Retinal Pigment Epithelium Thickness and Reflectivity, in Relation to Histology and Vision, at the Aging-AMD Transition: ALSTAR2 Baseline.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Stress Inference in Retinal Pigment Epithelium in C57BL/6J Mouse.Investigative ophthalmology & visual science · 2026Article
- Visible Light Optical Coherence Tomography Reveals Aging at the Retinal Pigment Epithelium-Bruch's Membrane Interface.bioRxiv : the preprint server for biology · 2026Article
- Preserved Contrast Sensitivity in Early and Intermediate Age-Related Macular Degeneration and Marked Loss in Late Stage: ALSTAR2.Investigative ophthalmology & visual science · 2026Article
- Hypertransmission and Vision in Aging and Age-Related Macular Degeneration: Longitudinal Data From ALSTAR2.American journal of ophthalmology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Purpose: The retinal pigment epithelium (RPE) is critical in age-related macular degeneration (AMD) pathophysiology. We compare total RPE thickness (TRPET) and normalized reflectivity intensity (TNRR) on optical coherence tomography (OCT) among healthy aged and early AMD (eAMD) and intermediate AMD (iAMD) eyes, and to visual function. Methods: Spectralis OCT volume scans from aged, eAMD, and iAMD eyes (per Age-Related Eye Disease Study [AREDS] 9-step) of the Alabama Study on Early Age-related Macular Degeneration 2 (ALSTAR2) baseline sample were automatically segmented for vitreous, nerve fiber layer (NFL), and total RPE (measured up to the centerline of the interdigitation zone) and manually corrected. TNRR was normalized with reference to vitreous and NFL within zones of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. Vision tests included rod-mediated dark adaptation (RMDA), a functional benchmark for AMD risk (reported as rod intercept time [RIT]), and other tests of rod- and cone-mediated function. Results: Of 502 eyes of 502 participants (71.8 ± 6.1 years, 59.6% female participants), 252 were healthy, 147 had eAMD, and 103 had iAMD. TRPET was significantly thinner in iAMD compared with eAMD and healthy eyes (P < 0.001) and moderately correlated with longer RIT in all eyes (r = 0.12-0.35). TNRR was lower in iAMD eyes compared to eAMD and healthy eyes (P < 0.01); correlation with RIT was weaker but significant. Conclusions: Reduced TRPET and TNRR in AMD and their correlation with RMDA are statistically significant due to the large sample. Whether they have practical utility for AMD detection will be learned from ongoing longitudinal studies. In ALSTAR2, non-RPE layers may contribute to delayed RMDA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.