Evidence map›Paper›PMID 41143446›Full record

ArticleJournal of natural products2025

Arzanol Inhibits Human Dihydroorotate Dehydrogenase and Shows Antiviral Activity.

Marta Alberti, Martina Tamburello, Stefano Salamone, Giorgio Gallinella, Cinzia Sanna, Giovanni Battista Appendino, Marco L Lolli, Alberto Massarotti, Federica Pollastro, Riccardo Miggiano

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Insights into Molecular Mechanisms of Polyphenolic Compounds fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta AlbertiDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, 28100 Novara, Italy.ORCID 0000-0003-3827-7243
Martina TamburelloDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Stefano SalamoneDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, 28100 Novara, Italy.
Giorgio GallinellaDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Cinzia SannaDepartment of Life and Environmental Sciences, University of Cagliari, Via Sant'Ignazio da Laconi 13, 09123 Cagliari, Italy.
Giovanni Battista AppendinoDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, 28100 Novara, Italy.ORCID 0000-0002-4170-9919
Marco L LolliDepartment of Sciences and Drug Technology, University of Torino, Via P. Giuria 9, 10125 Torino, Italy.ORCID 0000-0002-3030-3163
Alberto MassarottiDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, 28100 Novara, Italy.ORCID 0000-0001-9306-8845
Federica PollastroDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, 28100 Novara, Italy.ORCID 0000-0002-0949-2799
Riccardo MiggianoDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, 28100 Novara, Italy.ORCID 0000-0002-2159-3314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human dihydroorotate dehydrogenase (

Indexed as

Antiviral AgentsEnzyme InhibitorsOxidoreductases Acting on CH-CH Group DonorsPyronesDihydroorotate DehydrogenaseHumansMolecular StructureSARS-CoV-2UbiquinoneAntiviral AgentsDihydroorotate DehydrogenaseEnzyme InhibitorsOxidoreductases Acting on CH-CH Group DonorsPyronesUbiquinone

Identifiers

PMID41143446
PMCPMC12670699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.