Evidence map›Paper›PMID 41143334›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Efficacy and cost-effectiveness of extended nursing roles in dementia care: Results of the cluster-randomized trial InDePendent.

Anika Rädke, Bernhard Michalowsky, Fabian Kleinke, Moritz Platen, Annelie Scharf, Michelle Pfaff, Maresa Buchholz, Franka Mühlichen, Peter Penndorf, Stefanie Schade and 7 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04741932 (Interprofessional Dementia Care), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04741932 nacompletednot on this map

Interprofessional Dementia Care: Redistribution of Tasks Between Physicians and Qualified Nurses in Primary Care

TypeinterventionalSponsorGerman Center for Neurodegenerative Diseases (DZNE)Ran2021 to 2023Enrolled471ConditionsDementia, Nurse's Role, Nurse Physician RelationsArmsDementia Care Management (DCM)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anika RädkeGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Bernhard MichalowskyGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Fabian KleinkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Moritz PlatenGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Annelie ScharfGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Michelle PfaffGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Maresa BuchholzGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Franka MühlichenGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Peter PenndorfInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Stefanie SchadeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Janina DombrowskiInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Pia Elisa Madaida LerchAOK Nordost - Die Gesundheitskasse, Versorgungsprogramme und Verträge, Potsdam, Brandenburg, Germany.
Katrin Christiane ReberAOK Nordost - Die Gesundheitskasse, Versorgungsprogramme und Verträge, Potsdam, Brandenburg, Germany.
Manon Austenat-WiedTechniker Krankenkasse, Landesvertretung Mecklenburg-Vorpommern, Schwerin, Mecklenburg-Vorpommern, Germany.
Cornelia MartensTechniker Krankenkasse, Landesvertretung Mecklenburg-Vorpommern, Schwerin, Mecklenburg-Vorpommern, Germany.
Neeltje van den BergInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Wolfgang HoffmannGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.

Funding

German Innovation Fund of the Federal Joint Committee (G-BA) 01NVF18034
6 · The paper itself

Abstract

introductionExtended nursing roles in dementia can improve treatment, care, and patient and caregiver outcomes. We tested the efficacy and cost-effectiveness in people living with dementia (PlwD) and caregivers.

methodsWe analyzed data from 417 PlwD within the multicenter, cluster-randomized InDePendent trial six months after baseline. Specifically, qualified nurses carried out advanced dementia care management individually tailored to each patient's and caregiver's needs. Outcomes included unmet needs (CANE), quality of life (QoL-AD, EQ-5D), caregiver burden (Zarit), and cost-effectiveness (FIMA, RUD).

resultsPlwD receiving the intervention had 74% lower unmet needs (0.26, CI DISCUSSION: The results provide evidence for the efficacy and cost-effectiveness of extended nursing roles in dementia care, demonstrating that extended nursing roles reduce unmet needs and improve quality of life.

trial registrationThis trial was prospectively registered on ClinicalTrials.gov under the identifier NCT04741932 on February 2, 2021. HIGHLIGHTS: The InDePendent intervention significantly reduced the number of unmet needs in PlwD and their caregiver according to CANE. Extended nursing roles can improve PlwD's health-related Quality of Life. Advanced dementia care management were likely to be cost-effective after six months.

Indexed as

CaregiversCost-Benefit AnalysisDementiaNurse's RoleAgedAged, 80 and overFemaleHumansMaleQuality-Adjusted Life YearsQuality of Lifeadvanced nursingcost‐effectivenessdementiaprimary carerandomized controlled trialunmet needs

Identifiers

PMID41143334
PMCPMC12556587

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.