Evidence map›Paper›PMID 41143324›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2025

Tremor and disability outcomes following deep brain stimulation for multiple sclerosis-associated tremor.

Samantha A Banks, Matthew R Baker, Eoin P Flanagan, Fiona E Permezel, Lauren M Jackson, W Oliver Tobin, Orhun H Kantarci, B Mark Keegan, Sean J Pittock, Kai J Miller and 1 more

Abstract read
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In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samantha A BanksDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5856-1367
Matthew R BakerDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Eoin P FlanaganDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-6661-2910
Fiona E PermezelDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Lauren M JacksonDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
W Oliver TobinDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8141-2394
Orhun H KantarciDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
B Mark KeeganDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2880-935X
Sean J PittockDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8387-6491
Kai J MillerDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Bryan T KlassenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in HumansU01NS128612 · NINDS · MAYO CLINIC ROCHESTER · PI Peter Brunner, Kai Miller · 2022 to 2026
$4.5M
Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEGUH3NS123066 · NINDS · MAYO CLINIC ROCHESTER · PI Benjamin H Brinkmann, Gregory A Worrell · 2025 to 2026
$1.4M
NCATS NIH HHS UL1 TR002377NINDS NIH HHS U01 NS128612NINDS NIH HHS UH3 NS123066
6 · The paper itself

Abstract

backgroundTremor in multiple sclerosis (MS) is often refractory to medications. Deep brain stimulation (DBS) may help, but possible side effects and disease exacerbation limit its use.

objectivesEvaluate outcomes of DBS for MS-associated tremor.

methodsRetrospective review of 18 patients with MS-associated tremor who underwent DBS, analyzing Expanded Disability Status Scale (EDSS) and Fahn-Tolosa-Marin (FTM) tremor scores.

resultsMedian age at surgery was 49.5 years (range, 28-75), with postoperative follow-up 2.5 years (range, 0-22). No relapses (0/18) or new lesions (0/8) occurred postoperatively. All had ventral intermediate nucleus leads; other targets were not used in programming. EDSS remained stable (median 6 to 6.25;

conclusionsDBS is a potential treatment for severe MS tremor and did not provoke relapse. Targeting VIM alone may optimize tremor control and maintain magnetic resonance imaging (MRI) access.

Indexed as

Deep Brain StimulationMultiple SclerosisTremorAdultAgedDisability EvaluationFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment Outcomedeep brain stimulationDisability Status Scale (EDSS)Multiple sclerosistremor

Identifiers

PMID41143324
PMCPMC12744772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.