Evidence map›Paper›PMID 41143284›Full record

ArticleEJHaem2025

Epcoritamab for Relapsed/Refractory EBV+ Post-Transplant Lymphoproliferative Disorder of DLBCL-Type.

Li Yuan Chan, Simon O'Connor, Dima El-Sharkawi, Sunil Iyengar

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li Yuan ChanDepartment of Haemato-Oncology The Royal Marsden NHS Foundation Trust Sutton UK.ORCID https://orcid.org/0000-0003-3737-0905
Simon O'ConnorDepartment of Haemato-Oncology The Royal Marsden NHS Foundation Trust Sutton UK.
Dima El-SharkawiDepartment of Haemato-Oncology The Royal Marsden NHS Foundation Trust Sutton UK.ORCID https://orcid.org/0000-0002-2752-5814
Sunil IyengarDepartment of Haemato-Oncology The Royal Marsden NHS Foundation Trust Sutton UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with relapsed/refractory post-transplant lymphoproliferative disorder (R/R PTLD) following solid-organ transplants (SOT) or hematopoietic stem cell transplants (HSCT) after frontline chemoimmunotherapy have dismal outcomes. There is no standard of care for this group of patients, and they are generally excluded or ineligible for clinical trials. Several effective novel agents have been licensed in recent years for the treatment of diffuse large b-cell lymphoma (DLBCL), including CD19 CAR-T cell therapy and CD3xCD20 bispecific antibody. Case Report: Acknowledging the limited data and extrapolating the evidence from trials in DLBCL, we report a case of R/R PTLD successfully treated with CD3xCD20 bispecific antibody, Epcoritamab, with good tolerability and long-term response. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

Indexed as

bispecific antibodiesdiffuse large b‐cell lymphomaEBVpost‐transplant lymphoproliferative disorders

Identifiers

PMID41143284
PMCPMC12552892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.