Evidence map›Paper›PMID 41143193›Full record

ArticleFrontiers in cardiovascular medicine2025

Associations of angiopoietin-like protein 7 with coronary collateral circulation and prognosis of patients with severe coronary artery stenosis.

Congyi Cheng, Chunlin Wang, Weichun Zhu, Cong Su, Youran Dong, Junlin Teng, Kang Fu, Chungang Zhai, Lei Qiao, Wenqiang Chen

Abstract read
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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Congyi Cheng *State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Chunlin Wang *State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Weichun Zhu *State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Cong SuState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Youran DongState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Junlin TengState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Kang FuState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Chungang ZhaiState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Lei QiaoState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Wenqiang ChenState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Angiogenesis and coronary collateral circulation (CCC) formation promote cardiac repair following severe coronary stenosis (SCS) or myocardial infarction (MI). Angiopoietin-like protein 7 (ANGPTL7) is a secreted protein associated with angiogenesis, but its role in CCC formation remains unclear. Objective: The aim of this study was to investigate the role of ANGPTL7 in angiogenesis and evaluate the predictive value of serum ANGPTL7 in CCC formation and the prognosis of patients with SCS. Materials and methods: The RNA sequencing was performed on myocardial tissues of mice to analyze the alterations of angiogenesis-related genes after MI. 100 patients with angiographically proven SCS and 36 controls were enrolled and retrospectively followed up. Serum ANGPTL7 was measured by enzyme-linked immunosorbent assays (ELISA). Human umbilical vein endothelial cells (HUVECs) and exogenous human recombinant ANGPTL7 protein were applied in assays including CCK-8, scratch, tube formation, cell immunofluorescence and western blot to demonstrate the proangiogenic effect of ANGPTL7. Gene Set Enrichment Analysis (GSEA) was used to perform KEGG pathway enrichment analysis on downstream mechanisms by which ANGPTL7 promoted angiogenesis. Results: The transcriptional level of Conclusion: ANGPTL7 serves as a predictive biomarker for CCC levels and the prognosis of patients with SCS, which probably attributed to its proangiogenic properties.

Indexed as

angiogenesisangiopoietin-like protein 7clinical prognosiscoronary collateral circulationcoronary heart diseasesevere coronary stenosis

Identifiers

PMID41143193
PMCPMC12550588

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