ArticleFrontiers in cardiovascular medicine2025
Anatomic rupture location, leukocyte levels and diabetes mellitus as factors influencing in-hospital mortality following percutaneous repair of post-infarction ventricular septal rupture: a single centre study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Post-infarction ventricular septal rupture (PIVSR) carries high mortality despite therapeutic advances. This study evaluates outcomes and mortality predictors in 22 PIVSR patients treated at H. Adam Malik Hospital, Medan, where percutaneous closure has become preferred due to surgical limitations. Methods: This single-center, retrospective cohort study analyzed 22 consecutive patients with post-infarction ventricular rupture (January 2022-May 2025), stratified by closure eligibility ( Results: The non-closure group had higher leukocyte counts [14.9 ± 5.9 vs. 11.0 ± 4.0 × 10⁹/L, mean difference -3.9 (95% CI, -7.6 to -0.1) × 10 Conclusion: Percutaneous PIVSR closure improved survival, but outcomes depended on anatomic rupture location, with apical rupture exhibiting prevalent mortality in the closure group. Non-closure patients had shorter survival, higher leukocytes, and diabetes. While rupture location and systemic factors influenced results, further research is needed to explain these associations and optimize patient selection.
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