Evidence map›Paper›PMID 41143144›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2025

Prevalence of Diagnosed Essential Tremor in the United States: An Administrative Claims-Based Study.

Junji Lin, Rajesh Pahwa, Elan D Louis, Ragy Saad, Kelly E Lyons, Michael Markowitz, Liza R Gibbs, Aisara Chansakul, John Kroner, Douglas S Fuller and 5 more

Abstract read
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Junji LinJazz Pharmaceuticals, Palo Alto, CA, USA.ORCID 0000-0002-8475-6360
Rajesh PahwaUniversity of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0003-3176-6466
Elan D LouisUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-2062-362X
Ragy SaadJazz Pharmaceuticals, Palo Alto, CA, USA.ORCID 0000-0001-6117-5320
Kelly E LyonsUniversity of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0001-7418-1957
Michael MarkowitzJazz Pharmaceuticals, Palo Alto, CA, USA.
Liza R GibbsAetion Inc, New York, NY, USA.ORCID 0000-0002-6009-6839
Aisara ChansakulAetion Inc, New York, NY, USA.
John KronerAetion Inc, New York, NY, USA.ORCID 0000-0003-1674-9609
Douglas S FullerJazz Pharmaceuticals, Philadelphia, PA, USA.
Weiyi NiJazz Pharmaceuticals, Palo Alto, CA, USA.ORCID 0000-0003-4244-0699
Arthur SillahJazz Pharmaceuticals, Philadelphia, PA, USA.ORCID 0000-0003-1065-6735
Michelle BaladiJazz Pharmaceuticals, Palo Alto, CA, USA.ORCID 0009-0000-5285-2529
Luigi M BarbatoJazz Pharmaceuticals, Philadelphia, PA, USA.ORCID 0009-0008-6574-0604
Sanket ShahJazz Pharmaceuticals, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Essential tremor (ET) is one of the most common movement disorders. Previous estimates of ET prevalence vary due to multiple factors. This study estimated the prevalence of diagnosed ET. Methods: The prevalence of diagnosed ET was estimated among adults with continuous enrollment in 2022 and ≥1 additional year of prior baseline enrollment in the Merative™ MarketScan Results: The prevalence of diagnosed ET was 0.28% before age standardization, ranging from 0.06% (18-40 years) to 1.61% (≥75 years); 74% of patients overall received possible treatment. After standardization, prevalence was 0.42%; in 2024, 1.1 million US adults were estimated to have diagnosed ET. Estimates of the prevalence of diagnosed ET in the US were susceptible to the choice of case definition, nearly doubling (ie, 2.1 million US adults) with a more sensitive definition. Discussion: ET affects a substantial proportion of the US adult population. Selecting appropriate case definitions and using methods such as standardization are critical for estimating valid and generalizable chronic condition prevalences with real-world data. Highlights: This study found that 1.1 million US adults were estimated to have been diagnosed with essential tremor, with the sensitivity analyses yielding additional estimates. Estimating reliable and generalizable prevalences of diagnosed chronic conditions requires selection of appropriate case definitions and standardization to the general population.

Indexed as

Essential TremorAdolescentAdultAgedAged, 80 and overDatabases, FactualFemaleHumansInsurance Claim ReviewMaleMiddle AgedPrevalenceUnited StatesYoung Adultadministrative claimsessential tremorprevalencereal-world datareal-world evidence

Identifiers

PMID41143144
PMCPMC12551629

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.