Evidence map›Paper›PMID 41143142›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2025

Evaluation of Corneal Epithelial Thickness Across Different Stages of Diabetic Retinopathy Using Anterior Segment OCT.

Yongdong Lin, Zifeng Zhao, Di Ma, Yueting Ma, Shirong Chen, Chang Cai, Yongqun Xiong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yongdong LinDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People's Republic of China.ORCID 0000-0002-5693-9346
Zifeng ZhaoDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People's Republic of China.
Di MaDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People's Republic of China.
Yueting MaDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People's Republic of China.
Shirong ChenDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People's Republic of China.
Chang CaiDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People's Republic of China.
Yongqun XiongDepartment of Ophthalmology, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, People's Republic of China.ORCID 0009-0003-4271-6752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To compare the corneal epithelial thickness (CET), the density and number of central corneal subbasal nerve plexus (CSNP) between controls and different types of diabetic retinopathy in type 2 diabetics. Methods: This cross-sectional study included participants who underwent a comprehensive evaluation comprising anterior segment optical coherence tomography, Keratograph 5M, fluorescein tear break-up time, and in vivo confocal corneal microscopy. Based on the Early Treatment Diabetic Retinopathy Study classification, patients with diabetes were categorized into no diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. Results: A total of 75 eyes were examined- 20 eyes from 20 control subjects and 55 eyes from 55 patients with diabetes (20 NDR, 14 NPDR, 21 PDR). Compared to controls, diabetic eyes exhibited significant increases in corneal thickness (CT) in each region (all Conclusion: Diabetic eyes exhibit a reduction in CSNP density and number and an increase in CT. CET is significantly thinner in patients with PDR. Furthermore, CET correlates with CSNP density.

Indexed as

central corneal subbasal nervecorneal epithelial thicknesscorneal thicknessdiabetes mellitusocular surface parameter

Identifiers

PMID41143142
PMCPMC12553371

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.