ArticleResearch (Washington, D.C.)2025
Solid-Liquid Interface Lubricating Hydrogels for Tendon-Bone Healing.
Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Sprayable lipid-based lubricated hydrogel coating for alleviating catheter-related mucosal damage and pain.Bioactive materials · 2026Article
- Iontrovoltaic effect based on triboelectrically induced ion polarization at semiconductor-liquid interfaces.Nature communications · 2026Article
- Photosensitive and extracellular matrix-mimicking hydrogels promote the tendon-bone healing in rotator cuff injury.Journal of materials science. Materials in medicine · 2026Article
- A Biomimetic Scaffold for Single-Stage Reconstruction of Load-Bearing Segmental Bone Defects.BME frontiers · 2026Article
- The multidimensional roles and mechanisms of exercise intervention in pediatric oncology.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A solid-liquid interface lubrication system composed of tissue and synovial fluid ensures the physiological functions of the tendon-bone (TB). However, after the TB tears, stress concentration and friction disrupt the solid-liquid interface lubrication of the TB and disturb its healing. Herein, solid-liquid interface lubrication hydrogels (MnCaP/HS) are constructed by encapsulating ion-coordinated calcium manganese phosphate microgels into covalent/ionic-cross-linked hyaluronic acid/sodium alginate dual networks. Solid lubrication interfaces are thus formed at the damaged TB through surface hydrogen bonding and ionic toughening and continuously release the biolubrication components into tissue fluid for rolling lubrication layers and liquid lubrication films. This long-lasting lubricating property and MnCaP synergistically improve the immune-regenerative microenvironment of the TB. In vitro, MnCaP/HS increases the toughness by 600% and reduces the friction coefficient at the solid-liquid interface by 60% compared with those of the phosphate-buffered saline group. Moreover, it releases metal ions to promote the anti-inflammation of macrophages and the cartilage-bone gradient differentiation of bone marrow mesenchymal stem cells. In vivo, the maximum load and stiffness of tendons in the MnCaP/HS group increase by 102% and 75%, respectively while exerting long-lasting anti-inflammation to inhibit scarring and complete microstructural reconstruction. Thus, MnCaP/HS provides new solutions for TB reconstruction by providing long-lasting lubrication and a regenerative microenvironment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.