Evidence map›Paper›PMID 41143104›Full record

ArticleVirus evolution2025

Retrospective detection of severe fever with thrombocytopenia syndrome virus (SFTSV) revises timeline of emergence in Thailand.

Lester J Perez, Yupin Suputtamongkol, Abbas Hadji, Pakpoom Phoompoung, Sonja Weiss, Julie Yamaguchi, Kenn Forberg, Austin Hodges, Ana Olivo, Gavin A Cloherty and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lester J PerezInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.ORCID https://orcid.org/0000-0002-5717-5181
Yupin SuputtamongkolAbbott Pandemic Defense Coalition (APDC), 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Abbas HadjiInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Pakpoom PhoompoungAbbott Pandemic Defense Coalition (APDC), 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Sonja WeissInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Julie YamaguchiInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Kenn ForbergInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Austin HodgesInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Ana OlivoInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Gavin A ClohertyInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.
Michael G BergInfectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.ORCID https://orcid.org/0000-0003-0233-5819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To comprehend the time of emergence and extent of cryptic circulation for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Thailand, plasma specimens collected from patients at Siriraj Hospital, Bangkok, Thailand presenting with acute undifferentiated febrile illness (AUFI) were characterized by next-generation sequencing (NGS). Molecular and serological diagnostics were developed to screen for viral RNA and antibodies. Phylogenetic and phylogeographic analyses were performed using sequences generated from this study, publicly available genomes, and unsampled taxa to enhance temporal and geographic resolution. NGS detected SFTSV in 7 individuals with a median age of 73 years. Clinical manifestations ranged from low-grade fever and altered consciousness to multi-organ failure and death. RT-qPCR revealed three additional RNA positives, and antibody screening identified 38 IgG-positives for an incidence and prevalence of 0.4% and 2.7%, respectively. While SFTSV is reported as having been introduced into Thailand in 2019, evidence of infections dates back to 2012. Phylogenetic analyses revealed multiple introductions of Lineage 2 into Thailand around 2011-12, and phylogeographic reconstructions identified Thailand as a source for SFTSV spread to China and neighbouring countries. SFTSV has circulated cryptically in Thailand since 2012, diversifying locally and establishing endemicity. Genomic surveillance through improved diagnostics will be necessary to curb its spread through Asia and beyond.

Indexed as

diagnostic assaysduplex dual target RT-qPCRhigh throughput serologyphylodynamicsevere fever with thrombocytopenia syndrome virus

Identifiers

PMID41143104
PMCPMC12548732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.