ArticleJHLT open2025
Research for improvement of care for pediatric heart transplant patients.
Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past nearly-six decades since the first pediatric heart transplant, the field has made great strides. Yet, there remains substantial room for improvement. Wait time, graft longevity, cardiac allograft vasculopathy, rejection monitoring, and balancing immunosuppression with side effects remain significant challenges and affect patient quality of life. We review milestones in pediatric heart transplant research, including the formation of transplant registries, major multicenter prospective studies, and the first randomized clinical trial in pediatric heart transplantation. We discuss ongoing challenges to research in this field, including small population size, heterogeneity, and difficulty with identifying appropriate endpoints. We examine historical regulatory barriers and how they have been addressed to date. Future directions, including key areas of focus and funding pathways are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.