ArticleiScience2025
Human bronchial basal cells are a community of variants.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Extracellular vesicle-based delivery to airway basal cells for durable gene therapy in cystic fibrosis.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somatic cell gene editing and orthotopic transplantation have the potential to correct lung sequelae in monogenic diseases, including Cystic Fibrosis. Within the pseudostratified airway epithelium, basal cells (BC) serve as stem cells and are thought to be the optimal therapeutic target. However, the airway contains transcriptionally distinct BC, and emerging data suggest that these subtypes are variants rather than discrete entities. Since this ambiguity impedes therapy development, we investigated human BC diversity in systems that are frequently used to produce and test BC therapeutics. Single cell cloning and transcriptomics supported a transitional state model in which long-lived BC exist in a continuum that includes multipotential cells and those that are progressing toward a cycling or secretory fate. Functional analyses demonstrated that the environment determined the distribution of cells along the continuum. This plasticity supports the conclusion that BC are a community of variants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.